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Article
Open AccessPerception from students regarding online synchronous interactive teaching in the clinical year during COVID-19 pandemic
The global pandemic of COVID-19 has led to extensive practice of online learning. Our main objective is to compare different online synchronous interactive learning activities to evaluate students’ perceptions...
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Article
Online teaching of basic surgical skills to medical students during the COVID-19 pandemic: a case–control study
Medical education has been disrupted by the COVID-19 pandemic in many countries, with face-to-face lectures replaced by pre-recorded videos. However, surgical skills training cannot be replaced easily by video...
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Article
Open AccessA comparative study regarding distance learning and the conventional face-to-face approach conducted problem-based learning tutorial during the COVID-19 pandemic
Educational pedagogies were modified during the COVID-19 pandemic to minimise interruption to teaching. One approach has been the distance learning problem-based learning (PBL) tutorial utilising the online pe...
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Article
Open AccessAlterations in Gastric Microbiota After H. Pylori Eradication and in Different Histological Stages of Gastric Carcinogenesis
The role of bacteria other than Helicobacter pylori (HP) in the stomach remains elusive. We characterized the gastric microbiota in individuals with different histological stages of gastric carcinogenesis and aft...
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Article
Plasma miR-940 may serve as a novel biomarker for gastric cancer
It was reported that circulating microRNAs could be applied as non-invasive biomarkers for cancer monitoring. The purpose of this study was to identify plasma miRNA that may serve as a novel biomarker for gast...
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Article
Open AccessA three-miRNA signature as promising non-invasive diagnostic marker for gastric cancer
Despite the declining incidence of gastric cancer, mortality rate remains high due to late presentation. We aimed to evaluate the sensitivity of miRNA as a diagnostic marker for gastric cancer in the circulation.
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Article
Complete response of acquired FV inhibitor to rituximab
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Article
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer
Suet Yi Leung, Mao Mao and colleagues report whole-genome sequencing of 100 gastric cancers and DNA copy number, gene expression and methylation profiling of these tumors. They identify new recurrently mutated...
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Article
Open AccessA phase II trial of ixabepilone in Asian patients with advanced gastric cancer previously treated with fluoropyrimidine-based chemotherapy
The highest rates of gastric cancer occur in Eastern Asia. Fluoropyrimidine-based therapy is used initially in unresectable and metastatic disease, but no single standard of care exists following disease progr...
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Article
Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer
Suet Leung, Jiangchun Xu and colleagues report exome sequencing of 22 gastric cancers. They found that genes involved in chromatin modification were commonly mutated, including ARID1A encoding an SWI/SNF chromati...
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Reference Work Entry In depth
Peptic Ulcer Disease and Helicobacter Pylori
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Article
Open AccessMutations of PIK3CAin gastric adenocarcinoma
Activation of the phosphatidylinositol 3-kinase (PI3K) through mutational inactivation of PTEN tumour suppressor gene is common in diverse cancer types, but rarely reported in gastric cancer. Recently, mutations ...
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Article
Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles
Most GISTs require oncogenic activation of the KIT or PDGFRA receptor tyrosine kinase proteins, and the genomic mechanisms of oncogene activation are heterogeneous. Notably, the kinase mutation type correlates wi...
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Article
Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma
Promoter hypermethylation has become apparent as a common mechanism of gene silencing in cancer. Based on our published microarray expression data, we noticed a prominent downregulation of ID4 in gastric adenocar...
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Article
Comprehensive analysis of the gene expression profiles in human gastric cancer cell lines
Gastric adenocarcinoma is one of the major malignancies worldwide. Gastric cell lines have been widely used as the model to study the genetics, pharmacology and biochemistry of gastric cancers. Here we describ...
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Article
Intra-abdominal hypertension and abdominal compartment syndrome
Background: The effects of increased intra-abdominal pressure in various organ systems have been noted over the past century. The concept of abdominal compartment syndrome has gained mor...
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Article
Intrahepatic cholangiocarcinoma in Hong Kong
We retrospectively analyzed the results of hepatic resection for patients with intrahepatic cholangiocarcinoma managed between December 1966 and January 1998 at the University of Hong Kong Medical Center, Que...
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Article
Intrahepatic Cholangiocarcinoma
p < 0.02) or hilar nodal metastases ( p < 0.0003) survived significantly longer. We concluded that hepatic resection is indicated for intrahepati...
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Chapter and Conference Paper
Pancreaticoduodenectomy in Hong Kong: An Audit of the Queen Mary Hospital Experience
Pancreaticoduodenectomy is an established procedure for various periampullary cancers in Hong Kong. During the past decade, tumors at the head of the pancreas (27 patients), the ampulla (23 patients), and the ...
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Article
Endoscopic Sphincterotomy: 7-Year Experience
n = 33), and procedure-related mortality was 0.7% ( n = 5). There was a significant decrease in hospital mortality ( p ...
