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Article
Minimalist approach to donor hepatectomy
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Article
Criteria for liver transplantation in ACLF and outcome
Liver transplantation (LT) remains the only curative treatment for patients with failed medical treatment for acute-on-chronic liver failure (ACLF). However, the selection criteria for LT in ACLF is ill-define...
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Article
Open AccessCopy number gain of granulin-epithelin precursor (GEP) at chromosome 17q21 associates with overexpression in human liver cancer
Granulin-epithelin precursor (GEP), a secretory growth factor, demonstrated overexpression in various human cancers, however, mechanism remain elusive. Primary liver cancer, hepatocellular carcinoma (HCC), ran...
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Article
Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinoma
This study was designed to evaluate the efficacy, safety profile, pharmacokinetics, pharmacodynamics and quality of life of pegylated recombinant human arginase 1 (Peg-rhAgr1) in patients with advanced hepatoc...
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Article
Open AccessEstablishment and characterization of a novel primary hepatocellular carcinoma cell line with metastatic ability in vivo
Hepatocellular carcinoma (HCC) is a highly aggressive and heterogeneous disease. HCC cell lines established from different patients would be useful in elucidating the molecular pathogenesis. However, success o...
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Article
Prognostic Marker MicroRNA-125b Inhibits Tumorigenic Properties of Hepatocellular Carcinoma Cells Via Suppressing Tumorigenic Molecule eIF5A2
MicroRNAs (miRNAs) belong to a group of small non-coding RNA with differential expression in tumors, including hepatocellular carcinoma (HCC).
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Article
Open AccessClinical relevance and therapeutic potential of angiopoietin-like protein 4 in hepatocellular carcinoma
Development of novel adjuvant therapy to eradicate tumor angiogenesis and metastasis is a pressing need for patients with advanced hepatocellular carcinoma (HCC). We aimed to investigate the clinical relevance...
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Article
Surgical Outcomes in Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombosis
Different approaches to surgical treatment of portal vein tumor thrombosis (PVTT) have been advocated. This study investigated the outcomes of different surgical approaches in hepatocellular carcinoma (HCC) pa...
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Article
TG13 surgical management of acute cholecystitis
Laparoscopic cholecystectomy is now accepted as a surgical procedure for acute cholecystitis when it is performed by an expert surgeon. There are several lines of strong evidence, such as randomized controlled...
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Article
TG13 guidelines for diagnosis and severity grading of acute cholangitis (with videos)
Since the publication of the Tokyo Guidelines for the management of acute cholangitis and cholecystitis (TG07), diagnostic criteria and severity assessment criteria for acute cholangitis have been presented an...
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Article
Hepatocellular carcinoma—resection or transplant?
Hepatocellular carcinoma (HCC) is the fifth most common malignancy in the world, yet consensus is lacking on whether to treat patients with resection or transplantation. In this Perspectives, Sheung Tat Fan di...
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Article
Open AccessTolerance of High-Intensity Focused Ultrasound Ablation in Patients with Hepatocellular Carcinoma
High-intensity focused ultrasound (HIFU) ablation is a relatively new, noninvasive way of ablation for treating hepatocellular carcinoma (HCC). Emerging evidence has shown that it is effective for the treatmen...
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Article
Open AccessNew diagnostic criteria and severity assessment of acute cholecystitis in revised Tokyo guidelines
The Tokyo Guidelines for the management of acute cholangitis and cholecystitis (TG07) were published in 2007 as the world’s first guidelines for acute cholangitis and cholecystitis. The diagnostic criteria and...
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Article
Open AccessNew diagnostic criteria and severity assessment of acute cholangitis in revised Tokyo guidelines
The Tokyo Guidelines for the management of acute cholangitis and cholecystitis were published in 2007 (TG07) and have been widely cited in the world literature. Because of new information that has been publish...
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Article
Open AccessRole of Portal Vein Embolization in Hepatocellular Carcinoma Management and Its Effect on Recurrence: A Case-control Study
Liver regeneration that occurs after portal vein embolization (PVE) may have adverse effects on the microscopic tumor foci in the residual liver mass in patients with hepatocellular carcinoma (HCC).
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Article
Open AccessHigh-intensity focused ultrasound as a treatment for colorectal liver metastasis in difficult position
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Article
Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
John Luk and colleagues report the sequencing of 81 hepatitis B virus (HBV)-positive and 7 HBV-negative hepatocellular carcinomas and matched normal tissues. They confirm recurrent integration events of HBV at TE...
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Article
Open AccessSurvival advantage of primary liver transplantation for hepatocellular carcinoma within the up-to-7 criteria with microvascular invasion
Microvascular invasion of hepatocellular carcinoma (HCC) is considered a poor prognostic factor of liver resection (LR) and liver transplantation (LT), but its significance for lesions within the up-to-7 crite...
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Article
Open AccessSurvival Analysis of Re-resection Versus Radiofrequency Ablation for Intrahepatic Recurrence After Hepatectomy for Hepatocellular Carcinoma
Tumor recurrence after resection of hepatocellular carcinoma is a common phenomenon. Re-resection and radiofrequency ablation (RFA) are good options for treating recurrent HCC. This study compared the efficacy...
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Article
Open AccessValidation of graft and standard liver size predictions in right liver living donor liver transplantation
To assess the accuracy of a formula derived from 159 living liver donors to estimate the liver size of a normal subject: standard liver weight (g) = 218 + body weight (kg) × 12.3 + 51 (if male). Standard liver...
