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Article
Subretinal injection in mice to study retinal physiology and disease
Subretinal injection (SRI) is a widely used technique in retinal research and can be used to deliver nucleic acids, small molecules, macromolecules, viruses, cells or biomaterials such as nanobeads. Here we de...
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Article
Open AccessNucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration
Nonfibrillar amyloid-β oligomers (AβOs) are a major component of drusen, the sub-retinal pigmented epithelium (RPE) extracellular deposits characteristic of age-related macular degeneration (AMD), a common cau...
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Article
Evaluation of retinal vessel quantity within individual retinal structural layers using optical coherence tomography angiography
To evaluate retinal vessel quantity within various retinal structural layers using optical coherence tomography angiography (OCTA).
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Article
A pilot study of fluorescence lifetime imaging ophthalmoscopy in preclinical Alzheimer’s disease
To investigate fluorescence lifetime imaging ophthalmoscopy (FLIO) findings in preclinical Alzheimer’s disease (AD).
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Article
Analysis of ocular inflammation in anterior chamber—involving uveitis using swept-source anterior segment OCT
To evaluate the utility of swept-source (SS) optical coherence tomography (OCT) to objectively analyze the degree of anterior chamber (AC) inflammation.
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Article
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration
Degeneration of the retinal pigment epithelium is a hallmark of geographic atrophy, a type of age-related macular degeneration. Kerur et al. show that this degeneration results from a multistep pathway in which m...