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  1. No Access

    Article

    Subretinal injection in mice to study retinal physiology and disease

    Subretinal injection (SRI) is a widely used technique in retinal research and can be used to deliver nucleic acids, small molecules, macromolecules, viruses, cells or biomaterials such as nanobeads. Here we de...

    Peirong Huang, Siddharth Narendran, Felipe Pereira, Shinichi Fukuda… in Nature Protocols (2022)

  2. Article

    Open Access

    Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration

    Nonfibrillar amyloid-β oligomers (AβOs) are a major component of drusen, the sub-retinal pigmented epithelium (RPE) extracellular deposits characteristic of age-related macular degeneration (AMD), a common cau...

    Siddharth Narendran, Felipe Pereira… in Signal Transduction and Targeted Therapy (2021)

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  3. No Access

    Article

    Evaluation of retinal vessel quantity within individual retinal structural layers using optical coherence tomography angiography

    To evaluate retinal vessel quantity within various retinal structural layers using optical coherence tomography angiography (OCTA).

    Karntida Chanwimol, Takao Hirano… in Graefe's Archive for Clinical and Experime… (2020)

  4. No Access

    Article

    A pilot study of fluorescence lifetime imaging ophthalmoscopy in preclinical Alzheimer’s disease

    To investigate fluorescence lifetime imaging ophthalmoscopy (FLIO) findings in preclinical Alzheimer’s disease (AD).

    SriniVas R. Sadda, Enrico Borrelli, Wenying Fan, Adel Ebraheem, Kenneth M. Marion… in Eye (2019)

  5. No Access

    Article

    Analysis of ocular inflammation in anterior chamber—involving uveitis using swept-source anterior segment OCT

    To evaluate the utility of swept-source (SS) optical coherence tomography (OCT) to objectively analyze the degree of anterior chamber (AC) inflammation.

    Elmira Baghdasaryan, Tudor C. Tepelus, Kenneth M. Marion… in International Ophthalmology (2019)

  6. No Access

    Article

    cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

    Degeneration of the retinal pigment epithelium is a hallmark of geographic atrophy, a type of age-related macular degeneration. Kerur et al. show that this degeneration results from a multistep pathway in which m...

    Nagaraj Kerur, Shinichi Fukuda, Daipayan Banerjee, Younghee Kim… in Nature Medicine (2018)