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  1. Article

    Open Access

    Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration

    Nonfibrillar amyloid-β oligomers (AβOs) are a major component of drusen, the sub-retinal pigmented epithelium (RPE) extracellular deposits characteristic of age-related macular degeneration (AMD), a common cau...

    Siddharth Narendran, Felipe Pereira… in Signal Transduction and Targeted Therapy (2021)

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  2. No Access

    Article

    cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

    Degeneration of the retinal pigment epithelium is a hallmark of geographic atrophy, a type of age-related macular degeneration. Kerur et al. show that this degeneration results from a multistep pathway in which m...

    Nagaraj Kerur, Shinichi Fukuda, Daipayan Banerjee, Younghee Kim… in Nature Medicine (2018)