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  1. Article

    Open Access

    Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus

    Intravenous corticosteroid is the mainstay for managing acute severe ulcerative colitis, but one-third of patients do not respond to intravenous corticosteroid. Tacrolimus, a salvage therapy before colectomy, ...

    Hiromichi Shimizu, Toshimitsu Fujii, Kenji Kinoshita, Ami Kawamoto in BMC Gastroenterology (2021)

  2. No Access

    Article

    Diagnostic and prognostic usefulness of N 1,N 8-diacetylspermidine and N 1,N 12-diacetylspermine in urine as novel markers of malignancy

    Recently, we found N 1,N 8-diacetylspermidine (Ac2Spd) and N 1,N 12-diacetylspermine (Ac2Spm) in human urine, and noted that their amount increased significantly in patients with urogenital malignancies. Previou...

    Kyoko Hiramatsu, Masayuki Sugimoto in Journal of Cancer Research and Clinical On… (1997)

  3. No Access

    Article

    Significance of urinaryN 1,N 8-diacetylspermidine andN 1,N 12-diacetylspermine as indicators of neoplastic diseases

    N 1,N 8-Diacetylspermidine (Ac2Spd) andN 1,N 12 diacetylspermine (Ac2Spm), the occurrence of which in healthy human urine was demonstrated recently, increased much more frequently and markedly than total polyami...

    Masayuki Sugimoto, Kyoko Hiramatsu in Journal of Cancer Research and Clinical On… (1995)