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Article
Open AccessIdentification, Characterization, and X-ray Crystallographic Analysis of a Novel Type of Lectin AJLec from the Sea Anemone Anthopleura japonica
A novel galactose-specific lectin, AJLec (18.5 kDa), was isolated from the sea anemone, Anthopleura japonica. AJLec was characterized using the hemagglutination assay, isothermal titration calorimetry (ITC), and ...
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Protocol
Isolation of Plastid Ribosomes
Plastid ribosomes are responsible for a large part of the protein synthesis in plant leaves, green algal cells, and the vast majority in the thalli of red algae. Plastid translation is necessary not only for p...
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Article
Prolongation of heart rate-corrected QT interval is a predictor of cardiac autonomic dysfunction in patients with systemic lupus erythematosus
Heart rate-corrected QT interval duration (QTc) has been shown to be related to cardiac autonomic dysfunction in patients with diabetes mellitus, although this association has not been previously described in ...
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Article
Safety and efficacy of mizoribine in patients with connective tissue diseases other than rheumatoid arthritis
The objective of this study was to examine the safety and efficacy of mizoribine (MZR), an inhibitor of inosine monophosphate dehydrogenase, in patients with connective tissue diseases (CTDs) other than rheuma...
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Article
A case of infantile Takayasu arteritis with a p.D382E NOD2 mutation: an unusual phenotype of Blau syndrome/early-onset sarcoidosis?
Blau syndrome/early-onset sarcoidosis (Blau/EOS) is an autoinflammatory disease characterized by granulomatous arthritis, uveitis, and skin rash. It has been shown that gain-of-function NOD2 mutations cause Bl...
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Article
Infliximab for Behçet disease with aortic involvement: two novel case reports without concurrent use of immunosuppressive agents or corticosteroids
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Article
Open AccessEfficacy, pharmacokinetics, and safety of adalimumab in pediatric patients with juvenile idiopathic arthritis in Japan
The objective of this study was to evaluate the efficacy, pharmacokinetics, and safety of adalimumab in patients with polyarticular juvenile idiopathic arthritis (JIA) in Japan. Patients aged 4 to 17 years wer...
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Protocol
Preparation and Proteomic Analysis of Chloroplast Ribosomes
Proteomics of chloroplast ribosomes in spinach and Chlamydomonas revealed unique protein composition and structures of plastid ribosomes. These studies have suggested the presence of some ribosomal proteins uniqu...
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Article
Marked effect and steroid-sparing ability of anakinra on a patient with refractory adult-onset Still’s disease
We report a case of refractory adult-onset Still’s disease (AOSD) successfully controlled with anakinra, an interleukin-1 (IL-1) receptor antagonist. The patient was a 23-year-old Japanese woman with AOSD who ...
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Article
Producing mechanism of an algicidal compound against red tide phytoplankton in a marine bacterium γ-proteobacterium
Strain MS-02-063, γ-proteobacterium, isolated from a coast area of Nagasaki, Japan, produced a red pigment which belongs to prodigiosin members. This pigment, PG-L-1, showed potent algicidal activity against vari...
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Article
Comparison of the activities of various alginates to induce TNF-α secretion in RAW264.7 cells
We compared the abilities of alginate polymers having different molecular sizes and compositions to induce the secretion of tumor necrosis factor (TNF)-α in RAW264.7 cells. The molecular sizes and α-L-guluronate/...
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Article
Evaluation of the anti-Trichophyton activity of a prodigiosin analogue produced by γ-proteobacterium, using stratum corneum epidermis of the Yucatan micropig
Prodigiosins (PGs) are known to be a family of natural red pigments, characterized by a common pyrrolydipyrrolylmethane skeleton structure with a C-4 methoxy group, and some of these pigments have been isolate...
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Chapter
Transcriptional and Translational Regulation of Photosystem II Gene Expression
The plastid gene expression system employs a highly developed transcription and translation system that is an elaborated prokaryotic and eukaryotic chimera. Photosystem II (PS II) gene expression is regulated ...
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Article
The translational apparatus of Chlamydomonas reinhardtii chloroplast
Genetic and biochemical studies have revealed that chloroplast gene expression in Chlamydomonas is controlled primarily post-transcriptionally, including events that effect mRNA processing and stability, and duri...
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Article
Expression of Mcl-1 and p53 proteins predicts the survival of patients with T3 gastric carcinoma
The expression of myeloid cell leukemia 1 (Mcl-1) and p53 proteins was investigated for clinicopathological and prognostic significance in patients with gastric carcinoma.
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Article
The expression of RCAS1 and tumor infiltrating lymphocytes in patients with T3 gastric carcinoma
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Article
Intraspecific phenotypic variation associated with nuclear DNA content in Lolium perenne L.
The variation in nuclear DNA content and its association with phenotypic traits were examined in 15 cultivated populations of perennial ryegrass (Lolium perenne L.), including herbage and turf populations. Nuclea...
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Article
Combined resection of invaded organs in patients with T4 gastric carcinoma