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  1. Article

    Open Access

    Clinical characteristics of geriatric patients with non-specific chronic low back pain

    A comprehensive analysis of clinical information in patients with chronic low back pain (CLBP) was performed to clarify the clinical characteristics of geriatric LBP from the perspective of body composition, s...

    Yoshihito Sakai, Norimitsu Wakao, Hiroki Matsui, Tsuyoshi Watanabe in Scientific Reports (2022)

  2. Article

    Open Access

    Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model

    Accumulating evidence suggests that elevated inflammation contributes to the pathophysiology of post-traumatic stress disorder (PTSD) and that anti-inflammatory drugs might be a new treatment strategy for PTSD...

    Takehiko Yamanashi, Masaaki Iwata, Midori Shibushita in Scientific Reports (2020)

  3. Article

    Open Access

    Growth Factor Midkine Aggravates Pulmonary Arterial Hypertension via Surface Nucleolin

    Pulmonary arterial hypertension (PAH) is a progressive fatal disease caused by pulmonary arterial remodeling. Midkine regulates cell proliferation and migration, and it is induced by hypoxia, but its roles in ...

    Daisuke Kinoshita, Tetsuro Shishido, Tetsuya Takahashi in Scientific Reports (2020)

  4. Article

    Open Access

    Quantitative evaluation of digital-image enhancement during heads-up surgery

    Image-processing is an advantage of heads-up surgery and expected to facilitate ophthalmic surgeries. To evaluate image-processing quantitatively, we analyzed the surgical images of twenty eyes that underwent ...

    Kunihiko Akiyama, Ken Watanabe, Masaki Fukui, Hiroshi Higuchi in Scientific Reports (2019)

  5. No Access

    Article

    Diagnostic value of ultrasonography and TI-201/Tc-99m dual scintigraphy in differentiating between benign and malignant thyroid nodules

    To evaluate the performance of ultrasonography (US) and TI-201/Tc-99m dual (Tl/Tc) scintigraphy in differentiating between benign and malignant thyroid nodules.

    Ken Watanabe, Takao Igarashi, Hirokazu Ashida, Sho Ogiwara, Tomoyuki Ohta in Endocrine (2019)

  6. Article

    Open Access

    Soft and Robust Identification of Body Fluid Using Fourier Transform Infrared Spectroscopy and Chemometric Strategies for Forensic Analysis

    Body fluid (BF) identification is a critical part of a criminal investigation because of its ability to suggest how the crime was committed and to provide reliable origins of DNA. In contrast to current method...

    Ayari Takamura, Ken Watanabe, Tomoko Akutsu, Takeaki Ozawa in Scientific Reports (2018)

  7. Article

    Open Access

    Structure-based drug discovery for combating influenza virus by targeting the PA–PB1 interaction

    Influenza virus infections are serious public health concerns throughout the world. The development of compounds with novel mechanisms of action is urgently required due to the emergence of viruses with resist...

    Ken Watanabe, Takeshi Ishikawa, Hiroki Otaki, Satoshi Mizuta in Scientific Reports (2017)

  8. Article

    Open Access

    Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses

    Neuro-inflammation has been shown to play a critical role in the development of depression. Beta-hydroxybutyrate (BHB) is a ketone body and has recently been reported to exert anti-inflammatory effects via inh...

    Takehiko Yamanashi, Masaaki Iwata, Naho Kamiya, Kyohei Tsunetomi in Scientific Reports (2017)

  9. Article

    Open Access

    Heart rate responses induced by acoustic tempo and its interaction with basal heart rate

    Many studies have revealed the influences of music on the autonomic nervous system (ANS). Since previous studies focused on the effects of acoustic tempo on the ANS, and humans have their own physiological osc...

    Ken Watanabe, Yuuki Ooishi, Makio Kashino in Scientific Reports (2017)

  10. Article

    Open Access

    Patterning nanofibrils through the templated growth of multiple modified amyloid peptides

    There has been considerable interest in the patterning of functionalized nanowires because of the potential applications of these materials to the construction of nanodevices. A variety of biomolecular buildin...

    Hiroki Sakai, Ken Watanabe, Fuki Kudoh, Rui Kamada, Yoshiro Chuman in Scientific Reports (2016)