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  1. Article

    Open Access

    The HLA-DRB1*09:01-DQB1*03:03 haplotype is associated with the risk for late-onset Alzheimer’s disease in APOE \({{\varepsilon }}\) 4–negative Japanese adults

    Late-onset Alzheimer’s disease (LOAD) is the most common cause of dementia among those older than 65 years. The onset of LOAD is influenced by neuroinflammation. The human leukocyte antigen (HLA) system is inv...

    Daichi Shigemizu, Koya Fukunaga, Akiko Yamakawa, Mutsumi Suganuma… in npj Aging (2024)

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  2. Article

    Open Access

    Effects of once-yearly zoledronic acid on bone density and incident vertebral fractures in nonmetastatic castration-sensitive prostate cancer patients with osteoporosis

    Androgen deprivation therapy (ADT) is the effective treating prostate cancer but is often accompanied by cancer treatment-induced bone loss (CTIBL), which impairs the patient’s quality of life. In patients wit...

    Daisuke Watanabe, Takahiro Kimura, Ken Watanabe, Hiromitsu Takano… in BMC Cancer (2021)

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  3. Article

    Open Access

    Deficiency of sphingomyelin synthase 1 but not sphingomyelin synthase 2 reduces bone formation due to impaired osteoblast differentiation

    There are two isoforms of sphingomyelin synthase (SMS): SMS1 and SMS2. SMS1 is located in the Golgi apparatus only while SMS2 is located in both the plasma membrane and the Golgi apparatus. SMS1 and SMS2 act s...

    Goichi Matsumoto, Chieko Hashizume, Ken Watanabe, Makoto Taniguchi… in Molecular Medicine (2019)

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