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Article
Open AccessLongitudinal analysis of 5-year refractive changes in a large Japanese population
Refractive changes are reportedly affected by age, sex, and current refractive error. To clarify the pattern of refractive changes in a Japanese population, we conducted a 5-year follow-up longitudinal analysi...
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Article
Open AccessGenetic control of CCL24, POR, and IL23R contributes to the pathogenesis of sarcoidosis
Sarcoidosis is a genetically complex systemic inflammatory disease that affects multiple organs. We present a GWAS of a Japanese cohort (700 sarcoidosis cases and 886 controls) with replication in independent ...
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Article
Optimal blood pressure targets for patients with hypertension: a systematic review and meta-analysis
Optimal blood pressure (BP) targets for hypertension have been an important clinical issue but have been elusive. The Systolic Blood Pressure Intervention Trial (SPRINT) showed significant benefits of intensiv...
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Article
Open AccessReduced secretion of parathyroid hormone and hypocalcemia in systemic heterozygous ATP2B1-null hypertensive mice
The ATP2B1 gene is associated with hypertension. We previously reported that systemic heterozygous ATP2B1-null (ATP2B1+/−) mice exhibited hypertension due to impaired endothelial nitric oxide synthase (eNOS) acti...
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Article
Open AccessThe effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice
ATP2B1 is a gene associated with hypertension. We reported previously that mice lacking ATP2B1 in vascular smooth muscle cells (VSMC ATP2B1 KO mice) exhibited high blood pressure and increased intracellular calci...
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Article
Open AccessEffects of tolvaptan in patients with chronic kidney disease and chronic heart failure
Tolvaptan, a vasopressin V2 receptor blocker, has a diuretic effect for patients with heart failure. However, there were a few data concerning the effects of tolvaptan in patients with chronic kidney disease (CKD...
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Article
Open AccessAn isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice
Epithelial sodium channels (ENaCs) play critical roles in the maintenance of fluid and electrolyte homeostasis and their genetic abnormalities cause one type of hereditary salt-sensitive hypertension, Liddle s...
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Article
Open AccessEfficacy of cyclosporine combination therapy for new-onset minimal change nephrotic syndrome in adults
Cyclosporine and prednisolone combination therapy has been used in the treatment of minimal change nephrotic syndrome (MCNS). However, few studies have evaluated the efficacy of cyclosporine combined with intr...
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Article
IL12B and IL23R gene SNPs in Japanese psoriasis
Psoriasis is a common human skin disease whereby abnormal production of inflammatory mediators is believed to play an important role in its pathogenesis. The IL12B gene, which encodes the shared IL-12p40 subunit ...
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Article
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci
Nobuhisa Mizuki and colleagues report a genome-wide association study for Behçet's disease, a chronic systemic inflammatory disorder, in a Japanese population. They identify variants at IL23R-IL12RB2 and IL10 ass...
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Article
Loss of nocturnal decline of blood pressure in non-diabetic patients with nephrotic syndrome in the early and middle stages of chronic kidney disease
In non-diabetic patients with nephrotic syndrome (NS) at early stages of chronic kidney disease, it remains unclear whether the degree of proteinuria affects the nocturnal blood pressure (BP) dip. We evaluated...
