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  1. Article

    Open Access

    Role of circulating endothelial progenitors in responsiveness to erythropoiesis-stimulating agents in hemodialysis patients

    Though treatment of anemia in chronic kidney disease (CKD) patients has been improved remarkably by erythropoiesis-stimulating agents (ESA), hypo-responsiveness to ESA poses a persistent problem in a subgroup ...

    Akira Ishimitsu, Hiroshi Satonaka, Masahito Furuichi… in Renal Replacement Therapy (2021)

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  2. No Access

    Article

    V-ATPase blockade reduces renal gluconeogenesis and improves insulin secretion in type 2 diabetic rats

    Vacuolar H+-adenosine triphosphatase (V-ATPase) stimulates vesicular acidification that may activate cytoplasmic enzymes, hormone secretion and membrane recycling of transporters. We investigated the effect of bl...

    Jun Hirao, Akihiro Tojo, Saaya Hatakeyama, Hiroshi Satonaka… in Hypertension Research (2020)

  3. No Access

    Article

    Optimal blood pressure targets for patients with hypertension: a systematic review and meta-analysis

    Optimal blood pressure (BP) targets for hypertension have been an important clinical issue but have been elusive. The Systolic Blood Pressure Intervention Trial (SPRINT) showed significant benefits of intensiv...

    Atsushi Sakima, Hiroshi Satonaka, Norifumi Nishida, Keisuke Yatsu… in Hypertension Research (2019)

  4. No Access

    Article

    Effects of atorvastatin and ezetimibe on endothelial function in dyslipidemic patients with chronic kidney disease

    Chronic kidney disease (CKD) is a staple risk factor not only for renal failure but also for cardiovascular diseases. In addition, because dyslipidemia facilitates atherosclerosis and renal dysfunction, antihy...

    Toshihiko Ishimitsu, Eri Ohno, Yasuhiko Ueno… in Clinical and Experimental Nephrology (2014)

  5. Article

    Aldosterone-induced osteopontin gene transcription in vascular smooth muscle cells involves glucocorticoid response element

    Osteopontin (OPN) is known to be one of the cytokines that is involved in the vascular inflammation caused by aldosterone (Aldo). Previous reports have shown that Aldo increases OPN transcripts, and the mechan...

    Arihiro Kiyosue, Daisuke Nagata, Masahiro Myojo, Tomohiko Sato… in Hypertension Research (2011)

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  6. Article

    A new constitutively active mutant of AMP-activated protein kinase inhibits anoxia-induced apoptosis of vascular endothelial cell

    The inhibition of apoptotic changes in vascular endothelial cells is important for preventing vascular damage from hypoxia. AMP-activated protein kinase (AMPK) has recently been identified as playing a role in...

    Daisuke Nagata, Arihiro Kiyosue, Masao Takahashi, Hiroshi Satonaka… in Hypertension Research (2009)

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