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Open AccessCorrection: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
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SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors
Mutant isocitrate dehydrogenase 1 (mIDH1) drives tumorigenesis via producing oncometabolite R-2-hydroxyglutarate (R-2-HG) across various tumor types. However, mIDH1 inhibitors appear only effective in hematolo...
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Open AccessCorrection to: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
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Article
Open AccessDiscovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
Non-small cell lung cancer (NSCLC) patients with activating EGFR mutations initially respond to first-generation EGFR inhibitors; however, the efficacy of these drugs is limited by acquired resistance driven b...
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The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc
Histone deacetylases (HDACs) play fundamental roles in the epigenetic regulation of gene expression and contribute to the growth, differentiation, and apoptosis of cancer cells. Although HDACs are recognized t...
