300 Result(s)
within
Ke** Zhang
Engineering
Biotechnology
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Chapter
Evaluation of the Reliability of cDNA Microarray Technique
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Chapter
Microfabricated Chip Electrophoresis Technology for DNA Analysis
In this report, two microfabricated chip electrophoresis techniques and several application studies were tested for rapid and high-resolution separation of double-stranded (ds)DNA. In one technique, low-viscos...
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The Application of Novel Multi-Functional Microarray Slides for Immobilization Biomolecules
Microarray has revolutionized the study of molecular biology, especially the application in clinical diagnostics. When used in clinical diagnostics, microarray has to meet a high degree of reproducibility, rel...
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Chapter
An Integrated Biochemoinformatics System for Drug Discovery
Chipscreen Biosciences, Ltd. (www.chipscreen.com) is a drug discovery company specialized in novel small molecule therapeutics. Chipscreen has developed a proprietary chemical genomics approach to accelerate t...
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Cell Based Sensing Technologies
Biosensor technology is the driving force in the development of biochips capable of detecting and analyzing biomolecules. A biosensor is a device that detects, records, and transmits information regarding a ph...
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Microarray and Fluidic Chip for Extracellular Sensing
In the past two decades, the biological and medical fields have seen great advances in the development of biosensors and biochips capable of characterizing and quantifying biomolecules. Biosensors incorporate ...
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Designed Self-assembling Peptide Nanobiomaterials
There are two complementary technologies that can be used in the production of biomaterials. In the ‘top-down’ approach, biomaterials are produced by polymerizing homogeneous monomers into covalently linked mi...
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Article
Open AccessRole of reaction kinetics and mass transport in glucose sensing with nanopillar array electrodes
The use of nanopillar array electrodes (NAEs) for biosensor applications was explored using a combined experimental and simulation approach to characterize the role of reaction kinetics and mass transport in g...
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Towards Affordable and Accessible Healthcare Systems
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Article
Open AccessA quantitative method for determining spatial discriminative capacity
The traditional two-point discrimination (TPD) test, a widely used tactile spatial acuity measure, has been criticized as being imprecise because it is based on subjective criteria and involves a number of non...
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Article
Open AccessTime-frequency component analysis of somatosensory evoked potentials in rats
Somatosensory evoked potential (SEP) signal usually contains a set of detailed temporal components measured and identified in a time domain, giving meaningful information on physiological mechanisms of the ner...
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Article
Open AccessAn adaptation model for trabecular bone at different mechanical levels
Bone has the ability to adapt to mechanical usage or other biophysical stimuli in terms of its mass and architecture, indicating that a certain mechanism exists for monitoring mechanical usage and controlling ...
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Article
Open AccessA Metabolic Biofuel Cell: Conversion of Human Leukocyte Metabolic Activity to Electrical Currents
An investigation of the electrochemical activity of human white blood cells (WBC) for biofuel cell (BFC) applications is described. WBCs isolated from whole human blood were suspended in PBS and introduced int...
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Article
Open AccessAn automated and simple method for brain MR image extraction
The extraction of brain tissue from magnetic resonance head images, is an important image processing step for the analyses of neuroimage data. The authors have developed an automated and simple brain extractio...
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Article
Open AccessBglBrick vectors and datasheets: A synthetic biology platform for gene expression
As engineered biological systems become more complex, it is increasingly common to express multiple operons from different plasmids and inducible expression systems within a single host cell. Optimizing such s...
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Open AccessThe role of oxygen-increased respirator in humans ascending to high altitude
Acute mountain sickness (AMS) is common for people who live in low altitude areas ascending to the high altitude. Many instruments have been developed to treat mild cases of AMS. However, long-lasting and port...
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Article
Open AccessMechanical strain promotes osteoblast ECM formation and improves its osteoinductive potential
The extracellular matrix (ECM) provides a supportive microenvironment for cells, which is suitable as a tissue engineering scaffold. Mechanical stimulus plays a significant role in the fate of osteoblast, sugg...
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Article
Open AccessFunctional connectivity-based signatures of schizophrenia revealed by multiclass pattern analysis of resting-state fMRI from schizophrenic patients and their healthy siblings
Recently, a growing number of neuroimaging studies have begun to investigate the brains of schizophrenic patients and their healthy siblings to identify heritable biomarkers of this complex disorder. The objec...
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Article
Open AccessThree-dimensional reconstruction of blood vessels in the rabbit eye by X-ray phase contrast imaging
A clear understanding of the blood vessels in the eye is helpful in the diagnosis and treatment of ophthalmic diseases, such as glaucoma. Conventional techniques such as micro-CT imaging and histology are not ...
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Article
Open AccessBrain extraction from cerebral MRI volume using a hybrid level set based active contour neighborhood model
The extraction of brain tissue from cerebral MRI volume is an important pre-procedure for neuroimage analyses. The authors have developed an accurate and robust brain extraction method using a hybrid level set...
