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Article
Abnormal Rhythms Associated with Persistent Left Superior Vena Cava
Extract: The electrocardiograms of 26 patients with persistent left superior vena cava (SVC) draining into the coronary sinus were reviewed. Left axis of P waves between +15 and −29 degrees was observed in nin...
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Article
Dilatation of the Ductus Arteriosus by Prostaglandins and Prostaglandin's Precursors
Summary: We studied the effects of prostaglandins and their precursors in animal models. Rabbit ductus arteriosus constricted rapidly after delivery. PGE1, PDE2, and arachidonic acid injected SC dilated the ductu...
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Article
Constriction of the Fetal Ductus Arteriosus by Glucocorticoid Hormones
Summary: Hydrocortisone, prednisolone, and betamethasone were injected into a rat that was 21 days pregnant, and the fetal ductus arteriosus was studied using the rapid whole-body freezing technique. All these...
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Article
Characteristic Morphology of the Constricted Fetal Ductus Arteriosus following Maternal Administration of Indomethacin
ABSTRACT: Indomethacin 10 mg/kg was administered to the maternal rat on the 21st day of pregnancy, and the fetal and neonatal ductus arteriosus were studied using the rapid whole-body freezing technique. The s...
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Chapter
Natural history and noninvasive of diagnosis of subpulmonic ventricular septal defect
Studies made on surgical as well as on autopsy cases of ventricular septal defect (VSD) at our Institute have indicated that after the (peri)membranous type of VSD, subpulmonic VSD (SPVSD; subarterial infundib...
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Chapter and Conference Paper
Cardiovascular Malformations in the Conotruncal Anomaly Face Syndrome
In 1976, we reported a peculiar facial appearance [1] specifically related to conotruncal anomalies of the heart that was thus named “conotruncal anomaly face” (CTAF) and was characterized by lateral displacem...
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Chapter and Conference Paper
Characteristic Constriction of the Fetal Ductus Arteriosus by Indomethacin Administered to the Mother Rat
The study of Sharpe et al. has shown that the fetal ductus arteriosus (DA) constricts following administration of indomethacin and sodium salicylate to pregnant rats [1]. Further studies on pharmacologic manip...
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Article
In Situ Morphology of the Heart and Great Vessels in Fetal and Newborn Rats
ABSTRACT. Morphology of the cardiac chambers and great vessels of fetal and neonatal rats was studied using the whole body freezing technique and by sectioning through the short axis of the heart with a freezi...
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Article
In Vivo Constriction of the Ductus Arteriosus by Nonsteroidal Antiinflammatory Drugs in Near-Term and Preterm Fetal Rats
ABSTRACT. Herein we report age differences of in vivo constriction of the fetal ductus arteriosus by nonsteroidal antiinflammatory drugs in near-term and preterm rats. Two potent nonsteroidal antiinflammatory dru...
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Article
Increased Constriction of the Ductus Arteriosus with Combined Administration of Indomethacin and Betamethasone in Fetal Rats
ABSTRACT: To find a better treatment for patent ductus arteriosus of preterm infants, we studied the combined effect of indomethacin and betamethasone on the fetal ductus in rats. We used a rapid whole-body fr...
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Article
Fetal Cardiovascular Effects of Nifedipine in Rats
ABSTRACT: In this study we clarify the fetal cardiovascular effects of nifedipine. Nifedipine was administered to near-term rats and cardiovascular morphology of the fetus was studied with a rapid whole-body f...
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Article
In Situ Morphology of the Ductus Venosus and Related Vessels in the Fetal and Neonatal Rat
ABSTRACT: In situ cross-sectional morphology of the ductus venosus and related vessels was studied after rapid whole-body freezing of the fetal and neonatal rat. In the fetus, the ductus venosus was open widely, ...
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Article
In Situ Morphology of the Foramen Ovale in the Fetal and Neonatal Rat
ABSTRACT: In situ cross-sectional morphology of the foramen ovale was studied after rapid whole-body freezing of the fetal and neonatal rat. In the fetus, the foramen ovale was open widely toward the left atrium ...
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Article
In Situ Morphology of the Aorta and Common Iliac Artery in the Fetal and Neonatal Rat
ABSTRACT: In situ cross-sectional morphology of the ascending, descending, and abdominal aorta and the common iliac arteries was studied after rapid, whole-body freezing of fetal and neonatal rats. In the fetus, ...
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Chapter and Conference Paper
Balloon Angioplasty of Pulmonary Artery Following Arterial Switch Operation for Complete Transposition of the Great Arteries
Twenty-eight patients with transposition of the great arteries underwent 39 balloon angioplasty procedures after the arterial switch operation. The mean age at dilation was 4.5 years (range, 0.7–10 years). The...
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Article
Developmental Changes in the Contractile System of the Mesenteric Small Artery of Rabbit
This study investigated developmental changes in the contractile system of the mesenteric small arteries of the rabbit. Arteries about 1 mm in length and 100-250 μm in internal diameter were dissected out from...
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Chapter and Conference Paper
Arrhythmias in Left Isomerism
Three features of arrhythmias in left isomerism are reported. Atrial rhythm is characteristically multiple and tends to slow, corresponding to a poorly developed sinus node in left isomerism. Atrioventricular ...
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Article
Developmental Changes in the Effect of Acidosis on Contraction, Intracellular pH, and Calcium in the Rabbit Mesenteric Small Artery
The purpose of the present study was to determine developmental changes in the effect of respiratory acidosis on vascular smooth muscle contraction. Vessel diameter, intracellular pH (pHi), and calcium concentrat...
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Article
Accelerated Maturation of Fetal Ductus Arteriosus by Maternally Administered Vitamin A in Rats
Maturation of fetal ductus arteriosus is associated with increased constriction in response to maternally administered indomethacin. Recently retinoic acid has been shown to be important in development of the ...
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Article
The Role of Nitric Oxide in Dilating the Fetal Ductus Arteriosus in Rats
Prostaglandin E is a major dilator of the fetal ductus arteriosus (DA), but the role of nitric in fetal ductal dilation has not been established. We studied the effects of a potent nitric oxide synthase inhibi...