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Chapter and Conference Paper
Dilatation of the Ductus Arteriosus by Diazoxide in Fetal and Neonatal Rats
We previously reported that ATP-sensitive potassium (KATP) channels regulate ductal constriction in response to oxygen [1]. Diazoxide is a KATP channel opener while the usefulness of diazoxide for hyperinsulinemi...
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Chapter and Conference Paper
Constriction of the Ductus Arteriosus with KATP Channel Inhibitors
The cause of fetal death by sulfonylureas (SUs), used for diabetes in pregnancy in the early 1960s, remained unsolved for decades. In 1993, Nakanishi discovered constriction of ductus arteriosus (DA) strips in...
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Chapter
Fetal and Neonatal Ductus Arteriosus Is Regulated with ATP-Sensitive Potassium Channel
The fetal patency and neonatal closure of the ductus arteriosus (DA) are regulated with oxygen and prostaglandins. The proposed oxygen sensors of fetal and neonatal DA include P450-endothelin and the Kv channe...
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Chapter and Conference Paper
Balloon Angioplasty of Pulmonary Artery Following Arterial Switch Operation for Complete Transposition of the Great Arteries
Twenty-eight patients with transposition of the great arteries underwent 39 balloon angioplasty procedures after the arterial switch operation. The mean age at dilation was 4.5 years (range, 0.7–10 years). The...
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Chapter and Conference Paper
Arrhythmias in Left Isomerism
Three features of arrhythmias in left isomerism are reported. Atrial rhythm is characteristically multiple and tends to slow, corresponding to a poorly developed sinus node in left isomerism. Atrioventricular ...
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Chapter
Natural history and noninvasive of diagnosis of subpulmonic ventricular septal defect
Studies made on surgical as well as on autopsy cases of ventricular septal defect (VSD) at our Institute have indicated that after the (peri)membranous type of VSD, subpulmonic VSD (SPVSD; subarterial infundib...
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Chapter and Conference Paper
Cardiovascular Malformations in the Conotruncal Anomaly Face Syndrome
In 1976, we reported a peculiar facial appearance [1] specifically related to conotruncal anomalies of the heart that was thus named “conotruncal anomaly face” (CTAF) and was characterized by lateral displacem...
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Chapter and Conference Paper
Characteristic Constriction of the Fetal Ductus Arteriosus by Indomethacin Administered to the Mother Rat
The study of Sharpe et al. has shown that the fetal ductus arteriosus (DA) constricts following administration of indomethacin and sodium salicylate to pregnant rats [1]. Further studies on pharmacologic manip...