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Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes
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Trained immunity, tolerance, priming and differentiation: distinct immunological processes
The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and ...
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Open AccessIlluminating the human virome in health and disease
Although the microbiome is established as an important regulator of health and disease, the role of viruses that inhabit asymptomatic humans (collectively, the virome) is less defined. While we are still chara...
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Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells
A sedentary lifestyle, chronic inflammation and leukocytosis increase atherosclerosis; however, it remains unclear whether regular physical activity influences leukocyte production. Here we show that voluntary...
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Reply to ‘Questioning antiviral RNAi in mammals’
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Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells
Influenza A virus (IAV) causes annual epidemics and occasional pandemics, and is one of the best-characterized human RNA viral pathogens1. However, a physiologically relevant role for the RNA interference (RNAi) ...
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A quorum-sensing signal promotes host tolerance training through HDAC1-mediated epigenetic reprogramming
The mechanisms by which pathogens evade elimination without affecting host fitness are not well understood. For the pathogen Pseudomonas aeruginosa, this evasion appears to be triggered by excretion of the quorum...
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GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses
RIG-I–like receptors are important inducers of innate immunity. Reinecker and colleagues find that activation of the microtubule-associated guanine nucleotide exchange factor GEF-H1 is essential for sensing of...
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Suppression of the antiviral response by an influenza histone mimic
Viral infection is commonly associated with virus-driven hijacking of host proteins. Here we describe a novel mechanism by which influenza virus affects host cells through the interaction of influenza non-stru...
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Suppression of inflammation by a synthetic histone mimic
Small molecules that perturb chromatin proteins are an emerging focus of current biomedical research. Two groups reporting in this issue have targeted bromodomain-containing BET proteins that bind acetylated l...
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Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses
Dual-specificity phosphatases (DUSPs) are a subclass of protein tyrosine phosphatases (PTPs) that specifically interact with and regulate mitogen-activated pro...
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Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1
Mitogen-activated protein kinases facilitate many cellular processes and are essential for immune cell function. Their activity is controlled by kinases and dual-specificity phosphatases. A comprehensive micro...
