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    Article

    A Guide to Rational Dosing of Monoclonal Antibodies

    Dosing of therapeutic monoclonal antibodies (mAbs) is often based on body size, with the perception that body size-based dosing would reduce inter-subject variability in drug exposure. However, most mAbs are t...

    Dr Shuang Bai, Karin Jorga, Yan **n, Denise **, Yanan Zheng… in Clinical Pharmacokinetics (2012)

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    Article

    A Novel Strategy for Physiologically Based Predictions of Human Pharmacokinetics

    The major aim of this study was to develop a strategy for predicting human pharmacokinetics using physiologically based pharmacokinetic (PBPK) modelling. This was compared with allometry (of plasma concentrati...

    Dr Hannah M. Jones, Neil Parrott, Karin Jorga, Thierry Lavé in Clinical Pharmacokinetics (2006)