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  1. No Access

    Article

    A Guide to Rational Dosing of Monoclonal Antibodies

    Dosing of therapeutic monoclonal antibodies (mAbs) is often based on body size, with the perception that body size-based dosing would reduce inter-subject variability in drug exposure. However, most mAbs are t...

    Dr Shuang Bai, Karin Jorga, Yan **n, Denise **, Yanan Zheng… in Clinical Pharmacokinetics (2012)

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    Article

    A Novel Strategy for Physiologically Based Predictions of Human Pharmacokinetics

    The major aim of this study was to develop a strategy for predicting human pharmacokinetics using physiologically based pharmacokinetic (PBPK) modelling. This was compared with allometry (of plasma concentrati...

    Dr Hannah M. Jones, Neil Parrott, Karin Jorga, Thierry Lavé in Clinical Pharmacokinetics (2006)

  3. No Access

    Article

    The interaction of saquinavir (soft gelatin capsule) with ketoconazole, erythromycin and rifampicin: comparison of the effect in healthy volunteers and in HIV-infected patients

    Objective: The aim of this study was to compare the effect of ketoconazole, erythromycin and rifampicin on the pharmacokinetics of saquinavir soft-gelatin formulation (Fortovase; FTV) in healthy...

    Sibylle Grub, Helen Bryson, Tim Goggin… in European Journal of Clinical Pharmacology (2001)