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Author Correction: The power of genetic diversity in genome-wide association studies of lipids
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Open AccessImplicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understandi...
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Article
Open AccessTransferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals
Individuals with South Asian ancestry have a higher risk of heart disease than other groups but have been largely excluded from genetic research. Using data from 22,000 British Pakistani and Bangladeshi indivi...
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Article
Open AccessFine-scale population structure and demographic history of British Pakistanis
Previous genetic and public health research in the Pakistani population has focused on the role of consanguinity in increasing recessive disease risk, but little is known about its recent population history or...
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Article
The power of genetic diversity in genome-wide association studies of lipids
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treat...
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Article
Fine map** in the MHC region accounts for 18% additional genetic risk for celiac disease
Cisca Wijmenga and colleagues report fine map** of the association signal in the MHC region in individuals with celiac disease. They identify five additional risk factors that are independent of HLA-DQ allel...
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Article
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability
A search for variants in coding exons of 25 genome-wide association study risk genes in a large cohort of autoimmune patients finds that rare coding-region variants at known loci have a negligible role in comm...
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Article
Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry
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Dense genoty** identifies and localizes multiple common and rare variant association signals in celiac disease
David van Heel, Cisca Wijmenga and colleagues used a custom, high-density genoty** chip to examine 183 immune-related loci for their role in celiac disease. They report 13 new regions associated with celiac ...
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Correction: Corrigendum: Multiple common variants for celiac disease influencing immune gene expression
Nat. Genet.; doi:10.1038/ng.543; corrected online 12 March 2010 In the version of this article initially published online, the P value ranges in the second paragraph of the Results section under (iii) and (iv)...
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Multiple common variants for celiac disease influencing immune gene expression
David van Heel and colleagues report results of a large genome-wide association study of celiac disease. Most of the associated loci contain genes with immune functions, and over half harbor risk variants that...
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Open AccessComplex nature of SNP genotype effects on gene expression in primary human leucocytes
Genome wide association studies have been hugely successful in identifying disease risk variants, yet most variants do not lead to coding changes and how variants influence biological function is usually unknown.
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Article
Newly identified genetic risk variants for celiac disease related to the immune response
Our genome-wide association study of celiac disease previously identified risk variants in the IL2–IL21 region. To identify additional risk variants, we genotyped 1,020 of the most strongly associated non-HLA mar...
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Article
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 × 10−7) was in the KIAA1109-TENR-IL2-IL2...
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Article
Clinical and Radiologic Assessments to Predict Breast Cancer Pathologic Complete Response to Neoadjuvant Chemotherapy
To prospectively compare the ability of clinical examination, mammography, vascularity-sensitive ultrasound, and magnetic resonance imaging (MRI) to determine pathologic complete response (CR) in breast cance...
