Skip to main content

9 Result(s)

within Javier Gutierrez-Achury Remove this filter

and

  1. Article

    Open Access

    Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations

    In recent years, research has consistently proven the occurrence of genetic overlap across autoimmune diseases, which supports the existence of common pathogenic mechanisms in autoimmunity. The objective of th...

    Ana Márquez, Martin Kerick, Alexandra Zhernakova… in Genome Medicine (2018)

    Download PDF (1614 KB) View Article

  2. No Access

    Protocol

    Genetic Association in the HLA Region

    The MHC/HLA region has been consistently associated with a large number of complex traits, including but not limited to, most immune-mediated ones. Efforts to pinpoint drivers of this commonly encountered asso...

    Loukas Moutsianas, Javier Gutierrez-Achury in Genetic Epidemiology (2018)

  3. No Access

    Article

    Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

    Konstantinos Lazaridis, Carl Anderson and colleagues report results of a genome-wide association study of primary sclerosing cholangitis (PSC). They identify four new susceptibility loci for PSC and quantify t...

    Sun-Gou Ji, Brian D Juran, Sören Mucha, Trine Folseraas, Luke Jostins… in Nature Genetics (2017)

  4. No Access

    Article

    Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

    Jeffrey Barrett, Carl Anderson and colleagues report the results of a large genome-wide association study of inflammatory bowel disease. They identify 25 new genome-wide significant loci, 3 of which contain in...

    Katrina M de Lange, Loukas Moutsianas, James C Lee, Christopher A Lamb… in Nature Genetics (2017)

  5. No Access

    Article

    Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

    Soumya Raychaudhuri, Paul de Bakker and colleagues test the non-additive disease contributions of classical HLA alleles to five common autoimmune diseases. In four of the five diseases, they observe highly sig...

    Tobias L Lenz, Aaron J Deutsch, Buhm Han, **nli Hu, Yukinori Okada… in Nature Genetics (2015)

  6. No Access

    Article

    Fine map** in the MHC region accounts for 18% additional genetic risk for celiac disease

    Cisca Wijmenga and colleagues report fine map** of the association signal in the MHC region in individuals with celiac disease. They identify five additional risk factors that are independent of HLA-DQ allel...

    Javier Gutierrez-Achury, Alexandra Zhernakova, Sara L Pulit… in Nature Genetics (2015)

  7. No Access

    Article

    Dense genoty** of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

    Tom Karlsen and colleagues report an association study for primary sclerosing cholangitis (PSC), a severe liver disease, using the Immunochip array. They identify nine loci newly associated with PSC and examin...

    Jimmy Z Liu, Johannes Roksund Hov, Trine Folseraas, Eva Ellinghaus… in Nature Genetics (2013)

  8. No Access

    Article

    Identification of multiple independent susceptibility loci in the HLA region in Behçet's disease

    Amr Sawalha and colleagues performed dense genoty** in the HLA locus followed by imputation to fine map genetic variants associated with Behçet's disease in this region. They report four independent genetic ...

    Travis Hughes, Patrick Coit, Adam Adler, Vuslat Yilmaz, Kenan Aksu… in Nature Genetics (2013)

  9. No Access

    Article

    Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

    Eli Stahl, Robert Plenge and colleagues report the application of a polygenic analysis, using a Bayesian inference framework, to rheumatoid arthritis GWAS datasets. They find that polygenic risk scores are ass...

    Eli A Stahl, Daniel Wegmann, Gosia Trynka, Javier Gutierrez-Achury… in Nature Genetics (2012)