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    Article

    Characterizing Enoxaparin’s Population Pharmacokinetics to Guide Dose Individualization in the Pediatric Population

    Pediatric dosing of enoxaparin was derived based on extrapolation of the adult therapeutic range to children. However, a large fraction of children do not achieve therapeutic anticoagulation with initial dosin...

    Fernando O. Carreño, Jacqueline G. Gerhart, Victória E. Helfer… in Clinical Pharmacokinetics (2024)

  2. Article

    Open Access

    Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling

    While one in five children in the USA are now obese, and more than three-quarters receive at least one drug during childhood, there is limited dosing guidance for this vulnerable patient population. Physiologi...

    Jacqueline G. Gerhart, Fernando O. Carreño, Andrea N. Edginton… in Clinical Pharmacokinetics (2022)

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