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Article
Open AccessAbsence of physiological Ca2+ transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation
Motor neurons control muscle contraction by initiating action potentials in muscle. Denervation of muscle from motor neurons leads to muscle atrophy, which is linked to mitochondrial dysfunction. It is known t...
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Article
Open AccessMitochondrial Ca2+ uptake in skeletal muscle health and disease
Muscle uses Ca2+ as a messenger to control contraction and relies on ATP to maintain the intracellular Ca2+ homeostasis. Mitochondria are the major sub-cellular organelle of ATP production. With a negative inner ...
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Article
Open AccessSpatial temperature gradients guide axonal outgrowth
Formation of neural networks during development and regeneration after injury depends on accuracy of axonal pathfinding, which is primarily believed to be influenced by chemical cues. Recently, there is growin...
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Article
Open AccessOptical delivery of multiple opsin-encoding genes leads to targeted expression and white-light activation
In photodegenerative diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), progressive loss of vision occurs as a result of degeneration of the periphery of the retina and the ...
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Article
Open AccessIntroduction of impermeable actin-staining molecules to mammalian cells by optoporation
The selective insertion of foreign materials, such as fluorescent markers or plasmids, into living cells has been a challenging problem in cell biology due to the cell membrane's selective permeability. Howeve...
