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Chapter and Conference Paper
The 10.000/μl Morning Trigger for Prophylactic Platelet Transfusion is Safe: Prospective Experience in 411 AML Patients
There is an increasing demand for platelet transfusions and it remains an ongoing challenge for most blood centers to maintain an adequate platelet inventory. Platelet transfusions doubled in the US and in Can...
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Article
Interferon-αWirkung, Indikationen, Therapieüberwachung und Nebenwirkungen
Die Therapie mit Interferonen, insbesondere Interferon-α, hat in den letzten Jahren in der Behandlung chronischer Virusinfektionen sowie maligner Erkrankungen zunehmende Bedeutung erlangt. Der Behandlungserfol...
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Chapter
Philipp Franz von Siebold and His Era — Future Perspectives: Academic Cooperation and Exchange Between the Medical Faculties of the Universities of Würzburg and Leiden and Nagasaki University Medical School
In commemoration of the 200th anniversary of the birth of Philipp Franz von Siebold a Memorial International Medical Symposium with scientific contributions from the Universities of Nagasaki, Würzburg and Leid...
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Chapter and Conference Paper
Molecular Pathways of Topoisomerase II Regulation and Consequences for Chemotherapy
The DNA must be restructured continuously in all living and especially in proliferating cells. Conformational alteration is not only necessary for the constitution of chromosomes in mitosis but also for every ...
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Chapter and Conference Paper
Cellular and pharmacokinetic factors which influence genotoxicity of topoisomerase II inhibiting drugs in human leukemia cells
Multidrug resistance (MDR) is a cellular phenomenon which is defined by simultaneous development of resistance against cytostatic drugs from different chemical classes. The cells might even develop cross-resis...
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Article
Double blind controlled phase III multicenter clinical trial with interferon gamma in rheumatoid arthritis
The controlled clinical trial reported here is part of a multicenter clinical and basic research project, sponsored by the German Federal Minister of Science and Technology, directed by a standing commission o...
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Article
Failure to detect any effect of amalgam restorations on peripheral blood lymphocyte populations
Dental amalgam has been considered to have adverse side effects on the immune system. Reports have been contradictory, indicating both an increase and a decrease in peripheral blood lymphocyte counts associate...
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Article
γ/δ Receptor-expressing T-cell clones from a cutaneous T-cell lymphoma suppress hematopoiesis
Recently we described a cutaneous T-cell lymphoma expressing the γ/δ T-cell receptor [5]. The patient suffering from this lymphoma showed low numbers of myeloid and T cells in peripheral blood, while B and NK ...
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Article
Abstract
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Article
Scientific Proceedings Second International Symposium on Cytostatic Drug Resistance
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Chapter and Conference Paper
Grenzfälle in der internistischen Intensivtherapie
In Lehrbüchern der Intensivmedizin findet sich im allgemeinen nur der pauschale Hinweis, daß inkurable maligne Grunderkrankungen als Ausschlußkriterium für Reanimationsmaßnahmen zu gelten hätten. Eine angemess...
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Article
Absract
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Chapter
Interferone bei rheumatischen Erkrankungen
Die Aufklärung der Pathogenese entzündlich rheumatischer Erkrankungen, speziell der chronischen Polyarthritis (c. P.), und damit eine an der Pathogenese orientierte Therapie, ist bis heute ein ungelöstes Probl...
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Chapter
Vermehrung der Erythrozyten
Bei einer Vermehrung der Erythrozytenzahl bzw. des Hämatokrits sind differentialdiagnostisch ge-geneinander abzugrenzen:
Pseudopolyglobulie (Pseudoerythrozytose oder re-lative Erythroz...
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Chapter
Anämie
Eine Anämie liegt vor, wenn beim Mann der Hä-moglobinwert unter 14 g/dl, bei der Frau unter 12,5 g/dl beträgt. Die Grenzwerte für die Erythro- zytenzahl liegen bei 4,5.106 bzw. 4.106/μl. Für die Beurteilung des S...
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Chapter
RETRACTED CHAPTER: Zytokine in der klinischen Anwendung
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Article
Book reviews
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Article
Lung diseases after bone marrow transplantation
The case histories of 72 subsequently treated patients — 44 with acute leukemia, 10 with chronic myeloid leukemia, 16 with severe aplastic anemia and 2 with neuroblastoma — were analyzed after bone marrow tran...
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Article
Effektivere Behandlung der Peritonealkarzinose durch intraperitoneale Cis-Diamindichloroplatin (c-DDP)-Gabe mit systemischer Natriumthiosulfatprotektion
Thirteen patients with cytologically or histologically confirmed ascites from various malignancies have received 37 courses of intraperitoneal cis-platinum (cDDP). The tumor had to be confined to the peritonea...
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Article
Acute folic acid deficiency after bone marrow transplantation
After bone marrow transplantation (BMT), megaloblastic bone marrow changes are often observed that can only be partially explained by drug effects. Our goal was to find out whether folic acid deficiency repres...
