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  1. Article

    Open Access

    Zinc Gluconate Induces Potentially Cancer Chemopreventive Activity in Barrett’s Esophagus: A Phase 1 Pilot Study

    Chemopreventive effects of zinc for esophageal cancer have been well documented in animal models. This prospective study explores if a similar, potentially chemopreventive action can be seen in Barrett’s esoph...

    M. C. Valenzano, E. Rybakovsky, V. Chen, K. Leroy… in Digestive Diseases and Sciences (2021)

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  2. Article

    Open Access

    Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway

    Although the mechanism of Aβ action in the pathogenesis of Alzheimer’s disease (AD) has remained elusive, it is known to increase the expression of the antagonist of canonical wnt signalling, Dickkopf-1 (Dkk1)...

    R Killick, E M Ribe, R Al-Shawi, B Malik, C Hooper, C Fernandes… in Molecular Psychiatry (2014)

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  3. No Access

    Article

    STAT6 activity is regulated by SOCS-1 and modulates BCL-XL expression in primary mediastinal B-Cell lymphoma

    O Ritz, C Guiter, K Dorsch, I Dusanter-Fourt, S Wegener, H Jouault, P Gaulard… in Leukemia (2008)

  4. No Access

    Article

    The expression of 16 genes related to the cell of origin and immune response predicts survival in elderly patients with diffuse large B-cell lymphoma treated with CHOP and rituximab

    Gene expression profiles have been associated with clinical outcome in patients with diffuse large B-cell lymphoma (DLBCL) treated with anthracycline-containing chemotherapy. Using Affymetrix HU133A microarray...

    J-P Jais, C Haioun, T J Molina, D S Rickman, A de Reynies, F Berger… in Leukemia (2008)

  5. No Access

    Article

    Protocadherin 15 (PCDH15): a new secreted isoform and a potential marker for NK/T cell lymphomas

    Natural killer cells are well known to play an important role in immune defense against tumor development and viral infections. To further characterize new functionally relevant structures in these cells, we s...

    V Rouget-Quermalet, J Giustiniani, A Marie-Cardine, G Beaud, F Besnard… in Oncogene (2006)

  6. Article

    Open Access

    Cell cycle checkpoint status in human malignant mesothelioma cell lines: response to gamma radiation

    Knowledge of the function of the cell cycle checkpoints in tumour cells may be important to develop treatment strategies for human cancers. The protein p53 is an important factor that regulates cell cycle prog...

    C Vivo, C Lecomte, F Levy, K Leroy, Y Kirova, A Renier… in British Journal of Cancer (2003)

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  7. No Access

    Article

    Increase of adenomatous polyposis coli immunoreactivity is a marker of reactive astrocytes in Alzheimer's disease and in other pathological conditions

    Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene are responsible for colon cancer in familial adenomatous polyposis coli and in many sporadic colorectal tumors. The product of the APC g...

    K. Leroy, C. Duyckaerts, L. Bovekamp, O. Müller, B. Anderton… in Acta Neuropathologica (2001)