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STAT6 activity is regulated by SOCS-1 and modulates BCL-XL expression in primary mediastinal B-Cell lymphoma

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References

  1. Barth TF, Leithauser F, Joos S, Bentz M, Moller P . Mediastinal (thymic) large B-cell lymphoma: where do we stand? Lancet Oncol 2002; 3: 229–234.

    Article  PubMed  Google Scholar 

  2. Guiter C, Dusanter-Fourt I, Copie-Bergman C, Boulland ML, Le Gouvello S, Gaulard P et al. Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma. Blood 2004; 104: 543–549.

    Article  CAS  PubMed  Google Scholar 

  3. Skinnider BF, Mak TW . The role of cytokines in classical Hodgkin lymphoma. Blood 2002; 99: 4283–4297.

    Article  CAS  PubMed  Google Scholar 

  4. Wormald S, Hilton DJ . Inhibitors of cytokine signal transduction. J Biol Chem 2004; 279: 821–824.

    Article  CAS  PubMed  Google Scholar 

  5. Melzner I, Bucur AJ, Bruderlein S, Dorsch K, Hasel C, Barth TF et al. Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line. Blood 2005; 105: 2535–2542.

    Article  CAS  PubMed  Google Scholar 

  6. Melzner I, Weniger MA, Bucur AJ, Bruderlein S, Dorsch K, Hasel C et al. Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein. Int J Cancer 2006; 118: 1941–1944.

    Article  CAS  PubMed  Google Scholar 

  7. Mestre-Escorihuela C, Rubio-Moscardo F, Richter JA, Siebert R, Climent J, Fresquet V et al. Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas. Blood 2006; 109: 271–280.

    Article  PubMed  Google Scholar 

  8. Ushmorov A, Ritz O, Hummel M, Leithauser F, Moller P, Stein H et al. Epigenetic silencing of the immunoglobulin heavy-chain gene in classical Hodgkin lymphoma-derived cell lines contributes to the loss of immunoglobulin expression. Blood 2004; 104: 3326–3334.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We thank Adeline Henry for help in flow cytometry. We are thankful to William Hempel for careful reading and editing the paper.

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Correspondence to K Leroy.

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Ritz, O., Guiter, C., Dorsch, K. et al. STAT6 activity is regulated by SOCS-1 and modulates BCL-XL expression in primary mediastinal B-Cell lymphoma. Leukemia 22, 2106–2110 (2008). https://doi.org/10.1038/leu.2008.85

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