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  1. No Access

    Article

    In vivo arrhythmogenicity of the marine biotoxin azaspiracid-2 in rats

    Azaspiracids (AZAs) are marine biotoxins produced by the dinoflagellate Azadinium spinosum that accumulate in several shellfish species. Azaspiracid poisoning episodes have been described in humans due to ingesti...

    Sara F. Ferreiro, Natalia Vilariño, Cristina Carrera… in Archives of Toxicology (2014)

  2. No Access

    Article

    Asymmetric Synthesis of 3-Substituted 4-Oxoesters Using the SAMP-/RAMP-Hydrazone Method

    Based on aldehydes 1a—f or ketone 1g, 3-substituted 4-oxo esters 6a—g were synthesized in three steps in moderate to good overall yield (12—50%) and in excellent enantiomeric excesses (ee >90—>95%) by an Umpolung...

    D. Enders, U. Baus, P. Müller, K.C. Nicolaou, B. Jandeleit in Molecules Online (1998)

  3. No Access

    Article

    Total synthesis of brevetoxin A

    Brevetoxin A is the most potent neurotoxin secreted by Gymnodinium breve Davis, a marine organism often associated with harmful algal blooms known as ‘red tides’1,2,3. The compound, whose mechanism of action invo...

    K. C. Nicolaou, Zhen Yang, Guo-qiang Shi, Janet L. Gunzner… in Nature (1998)

  4. No Access

    Chapter

    Ring-Closing Metathesis in the Synthesis of Epothilones and Polyether Natural Products

    The increasing popularity of ring-closing metathesis (RCM) can be attributed to the development of transition metal complexes 1, 2 and 3 as initiators. These compounds efficiently promote the RCM process, are com...

    K. C. Nicolaou, N. Paul King, Yun He in Alkene Metathesis in Organic Synthesis (1998)

  5. Article

    Erratum: Synthesis of epothilones A and B in solid and solution phase

    Nature 387, 268–272; (1997) We wish to add that, as well as a total synthesis of epothilone B, reference 19 includes biological data for compound 23 and other congeners similar to those reported in our Letter.

    K. C. Nicolaou, N. Winssinger, J. Pastor, S. Ninkovic, F. Sarabia, Y. He… in Nature (1997)

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  6. No Access

    Article

    Synthesis of epothilones A and B in solid and solution phase

    Epothilones A and B, two compounds that have been recently isolated1 from myxobacterium Sorangium cellulosum strain 90, have generated intense interest2–16 among chemists, biologists and clinicians owing to the s...

    K. C. Nicolaou, N. Winssinger, J. Pastor, S. Ninkovic, F. Sarabia, Y. He… in Nature (1997)

  7. No Access

    Article

    Chemical self-replication of palindromic duplex DNA

    MOLECULAR replication, a fundamental process of life, has in recent years been the subject of laboratory investigations using simple chemical systems1–10. Whereas the work of Rebek's group4,5 has focused on molec...

    T. Li, K. C. Nicolaou in Nature (1994)

  8. No Access

    Article

    Total synthesis of taxol

    TAXOL1–4, a substance originally isolated from the Pacific yew tree (Taxus brevifolia) more than two decades ago, has recently been approved for the clinical treatment of cancer patients. Hailed as having provide...

    K. C. Nicolaou, Z. Yang, J. J. Liu, H. Ueno, P. G. Nantermet, R. K. Guy… in Nature (1994)

  9. No Access

    Article

    Design, synthesis and biological activity of protaxols

    TAXOL1–6 is a product isolated from the Pacific yew tree (Taxus brevifolia) and is a potent microtubule-stabilizing agent which has recently been approved for treatment of otherwise intractable ovarian cancer. De...

    K. C. Nicolaou, C. Riemer, M. A. Kerr, D. R. Rideout, W. W. Wrasidlo in Nature (1993)

  10. No Access

    Article

    Pheromone blends of green stink bugs and possible parasitoid selection

    J. R. Aldrich, W. R. Lusby, B. E. Marron, K. C. Nicolaou… in Naturwissenschaften (1989)

  11. No Access

    Article

    Pharmacodynamics of lipoxin A4 in airway smooth muscle

    S. -E. Dahlén, C. A. Veale, S. E. Webber, B. E. Marron… in Agents and Actions (1989)

  12. No Access

    Article

    Lipoxin A4 causes generation of thromboxane A2 in the guinea-pig lung

    E. Wikström, P. Westlund, K. C. Nicolaou, S. -E. Dahlén in Agents and Actions (1989)

  13. No Access

    Chapter and Conference Paper

    Aspects of Eicosanoids in Inflammation

    The microvascular system has a key role in host defence and expression of the inflammatory process which is indispensible for the elimination of foreign and noxious agents. Regardless of the nature of the init...

    Per Hedqvist, Sven-Erik Dahlén, Johan Raud, Lennart Lindbom… in Prostanoids and Drugs (1989)

  14. No Access

    Chapter

    The Total Synthesis of the Lipoxins and Related Compounds

    In 1984, a new class of arachidoníc acid derived products was discovered by Serhan et al.1–3 While studying lipoxygenase pathway interactions, these researchers isolated two major constituents from human leukocyt...

    S. E. Webber, C. A. Veale, K. C. Nicolaou in Lipoxins (1988)

  15. No Access

    Chapter

    Actions of Lipoxin A4 and Related Compounds in Smooth Muscle Preparations and on the Microcirculation in Vivo

    The present chapter summarizes our findings with lipoxins (LX) in spasmogenic assays and in the intact microvasculature of the hamster cheek pouch. The initial observations1,2 were made in experiments using lipox...

    Sven-Erik Dahlén, Lilian Franzén, Johan Raud, Eva Wikström, Thure Björck… in Lipoxins (1988)

  16. No Access

    Article

    Thromboxane synthetase inhibitors differentially antagonize thromboxane receptors in vascular smooth muscle

    A number of thromboxane (Tx) synthetase inhibitors have been found to prevent thromboxane release in acute cardiopulmonary disorders. However, little is known about Tx receptor antagonism by these substances. ...

    Edward F. Smith III, Allan M. Lefer… in Naunyn-Schmiedeberg's Archives of Pharmaco… (1981)

  17. No Access

    Article

    A triple test for screening biological activity of prostacyclin analogues

    6,9-Thiaprostacyclin was used as a representative of prostacyclin analogues with the aim to design the most convenient procedure for evaluation of vasodilator, anti-platelet and other biological properties wit...

    R. J. Gryglewski, K. C. Nicolaou in Experientia (1978)