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Article
Aminooxy analog of histamine is an efficient inhibitor of mammalian l-histidine decarboxylase: combined in silico and experimental evidence
Histamine plays highlighted roles in the development of many common, emergent and rare diseases. In mammals, histamine is formed by decarboxylation of l-histidine, which is catalyzed by pyridoxal-5′-phosphate (PL...
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Article
Erratum: Synthesis of epothilones A and B in solid and solution phase
Nature 387, 268–272; (1997) We wish to add that, as well as a total synthesis of epothilone B, reference 19 includes biological data for compound 23 and other congeners similar to those reported in our Letter.
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Article
Synthesis of epothilones A and B in solid and solution phase
Epothilones A and B, two compounds that have been recently isolated1 from myxobacterium Sorangium cellulosum strain 90, have generated intense interest2–16 among chemists, biologists and clinicians owing to the s...
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Article
AM1 study of Wolff and 1,2-hydrogen shift rearrangements of β-oxy-α-Diazo carbonyl compounds
The study of several thermal processes involved in the β-oxy-α-diazo carbonyl compounds chemistry at the AM 1 semiempirical level is reported. Principally, our study focussed on competitive Wolff and 1,2-hydri...