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Article
Diagnostik der Lungentuberkulose mit Ziehl-Neelsen-Färbung und Polymerasekettenreaktion
Die sichere Diagnostik unklarer pulmonaler Läsionen erfordert meist morphologische Methoden. Hier kommen Tumoren, entzündliche Prozesse und insbesondere eine Tuberkulose in Betracht. Ziel dieser Untersuchung w...
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Article
Oncogenic RAS simultaneously protects against anti-EGFR antibody-dependent cellular cytotoxicity and EGFR signaling blockade
Monoclonal antibodies against the epidermal growth factor receptor (EGFR) are effective cancer therapeutics, but tumors harboring RAS mutations are resistant. To functionally dissect RAS-mediated resistance, we h...
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Article
MicroRNA-Profile in der Feinnadelbiopsie der Schilddrüse
MicroRNAs (miRNAs) sind kleine (20–24 Nukleotide), nichtkodierende Ribonukleinsäuren, die durch Regulation der Genexpression auf der posttranskriptionalen Ebene in physiologische Prozesse wie Wachstum, Differe...
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Article
Open AccessDifferential miRNA expression profiles in variants of papillary thyroid carcinoma and encapsulated follicular thyroid tumours
Recent studies showed a significant upregulation of distinct microRNAs (miRNAs) in papillary thyroid carcinoma (PTC). The objective of this study was to explore whether this upregulation could also be assigned...
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Article
Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations
Signal transduction and modulation represent central mechanisms in cellular processes such as cell-cycle regulation, oncogenesis, and apoptosis. The aim of this study was to determine the prognostic relevance ...
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Article
Citalopram concentrations in samples from autopsies and living persons
Concentrations of citalopram in medicolegal samples from 92 autopsies and 27 living persons are described. In autopsy cases in which citalopram alone was the cause of death, concentrations ranged from 2.0 to ...
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Article
Fatal intoxications in Denmark following intake of morphine from opium poppies
In Denmark it is legal to grow opium poppies for the production of poppy seeds and until 1986 for decoration purposes, too. Danish poppy capsules contain 0.3–5 mg morphine per capsule and the content of morphi...