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MicroRNA-Profile in der Feinnadelbiopsie der Schilddrüse

MicroRNA profiles in fine needle biopsy of the thyroid

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Zusammenfassung

MicroRNAs (miRNAs) sind kleine (20–24 Nukleotide), nichtkodierende Ribonukleinsäuren, die durch Regulation der Genexpression auf der posttranskriptionalen Ebene in physiologische Prozesse wie Wachstum, Differenzierung und Apoptose eingreifen. Insbesondere für das papilläre Schilddrüsenkarzinom wurde eine typische Überexpression mehrerer miRNAs (u. a. miRNA 146b, 221 und 222) gezeigt. Im vorliegenden Artikel werden die Möglichkeiten und Probleme der miRNA-Analyse an durch Feinnadelbiopsie gewonnenem Material aus Schilddrüsenknoten beschrieben und diskutiert. Insbesondere die Analyse von definierten Kombinationen von miRNAs sollte zu einer Steigerung der Aussagekraft dieser Methode und einem verbesserten Management der Patienten mit hypofunktionellen Schilddrüsenknoten führen.

Abstract

MicroRNAs (miRNAs) are small (20–24 nucleotides), non-coding ribonucleid acids, which regulate gene expression on the post-transcriptional level, thus influencing physiological processes including cellular growth, differentiation and apoptosis. Several miRNAs (e. g. miRNAs 146b, 221 and 222) have been shown to be consistently over-expressed in papillary thyroid carcinoma. The present overview describes and discusses the utilization and problems of miRNA analysis in material from thyroid nodules obtained by fine needle biopsy. Particularly the analysis of defined sets of miRNAs should improve the diagnostic value of this procedure and contribute to a better management of patients with cold thyroid nodules.

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  1. Institut für Pathologie und Neuropathologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Deutschland

    S. Ting, S.-Y. Sheu-Grabellus, K. Worm & K.W. Schmid

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  1. S. Ting
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  2. S.-Y. Sheu-Grabellus
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  3. K. Worm
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  4. K.W. Schmid
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Correspondence to S. Ting.

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Ting, S., Sheu-Grabellus, SY., Worm, K. et al. MicroRNA-Profile in der Feinnadelbiopsie der Schilddrüse. Pathologe 33, 331–336 (2012). https://doi.org/10.1007/s00292-012-1581-0

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  • DOI: https://doi.org/10.1007/s00292-012-1581-0

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