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  1. No Access

    Article

    Anti-leukemic mechanisms of pegylated arginase I in acute lymphoblastic T-cell leukemia

    New treatments for adults with acute lymphoblastic T-cell leukemia (T-ALL) are urgently needed, as the current rate of overall remission in these patients is only about 40 percent. We recently showed the poten...

    K Morrow, C P Hernandez, P Raber, L Del Valle, A M Wilk, S Majumdar… in Leukemia (2013)

  2. No Access

    Article

    Molecular mimicry in inducing DNA damage between HIV-1 Vpr and the anticancer agent, cisplatin

    The human immunodeficiency virus type 1 (HIV-1) viral protein R (vpr) gene is an evolutionarily conserved gene among the primate lentiviruses. Several functions are attributed to Vpr including the ability to caus...

    K Siddiqui, L Del Valle, N Morellet, J Cui, M Ghafouri, R Mukerjee, K Urbanska… in Oncogene (2008)

  3. No Access

    Article

    Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3β constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines

    We have previously reported that insulin-like growth factor-I (IGF-I) supports growth and survival of mouse and human medulloblastoma cell lines, and that IGF-I receptor (IGF-IR) is constitutively phosphorylat...

    K Urbanska, J Trojanek, L Del Valle, M B Eldeen, F Hofmann, C Garcia-Echeverria… in Oncogene (2007)

  4. No Access

    Article

    Role of the interaction between large T antigen and Rb family members in the oncogenicity of JC virus

    Human polyomaviruses (JC virus, BK virus and simian virus 40) are causative agents of some human diseases and, interestingly, are involved in processes of cell transformation and oncogenesis. These viruses nee...

    V Caracciolo, K Reiss, K Khalili, G De Falco, A Giordano in Oncogene (2006)