46 Result(s)
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Article
Factors associated with the practice of nursing staff sharing information about patients’ nutritional status with their colleagues in hospitals
Nursing staff have an important role in patients’ nutritional care. The aim of this study was to demonstrate how the practice of sharing a patient’s nutritional status with colleagues was affected by the nursi...
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Article
Targeting Oct1 genomic function inhibits androgen receptor signaling and castration-resistant prostate cancer growth
Androgen receptor (AR) functions as a ligand-dependent transcription factor to regulate its downstream signaling for prostate cancer progression. AR complex formation by multiple transcription factors is impor...
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Open AccessDeletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse
JMJD2B is a histone demethylase enzyme that regulates gene expression through demethylation of H3K9me3. Although mutations of JMJD2B have been suggested to be responsible for neurodevelopmental disorders, the ...
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Article
Radiographic analysis of the progression of congenital scoliosis with rib anomalies during the growth period
Retrospective study.
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Effect of web-based lifestyle modification on weight control: a meta-analysis
Web-based treatment programs are attractive in primary care because of their ability to reach numerous individuals at low cost. Our aim of this meta-analysis is to systematically review the weight loss or main...
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Open AccessIncreased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling
The adiponectin signalling pathway is largely unknown, but recently the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1), has been shown to...
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Article
Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells
The mammalian target of rapamycin (mTOR) plays a central role in regulating the proliferation of malignant glioma cells, and mTOR-specific inhibitors such as rapamycin analogs are considered as promising thera...
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Novel high-affinity PPARγ agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1
Peroxisome proliferator-activated receptor gamma (PPARγ) agonists demonstrate antitumor activity likely through transactivating genes that regulate cell proliferation, apoptosis, and differentiation. The PAX8/PPA...
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Tetralogy of Fallot with Anomalous Origin of the Right Pulmonary Artery from the Ascending Aorta and Hypoplastic Left Pulmonary Artery
A case of tetralogy of Fallot associated with anomalous origin of the right pulmonary artery from the ascending aorta and hypoplastic left pulmonary artery was successfully repaired. Following the simultaneous...
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Article
Preliminary Study of Autologous Blood Predonation in Pediatric Open-Heart Surgery
We applied an autologous blood predonation protocol using recombinant human erythropoietin in pediatric open-heart surgery. The study included 69 children weighing 8 kg or more. Twice before operation, 8 ml/kg...
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Article
Effect of peripheral lipopolysaccharide injection on dopamine content in murine anterior olfactory nucleus
Norepinephrine turnover rate in the murine locus coeruleus (LC) is known to be enhanced by the intraperitoneal (i.p.) injection of lipopolysaccharide (LPS). Approximately 40% of LC neurons are also known to p...
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Article
Platelet-sparing effect of paclitaxel in heavily pretreated ovarian cancer patients
Carboplatin has proven to be effective in the treatment of patients with recurrent ovarian cancer who have responded to platinum-based first-line chemotherapy. However, thrombocytopenia is a problem in heavil...
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Article
Exon 3 of tyrosine hydroxylase gene: lack of association with Japanese schizophrenic patients
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine (DA) biosynthesis.1,2 Exon 3 of the human TH gene encodes the sequence from Ser31 to Glu104 of type 1 enzyme,3,4 which contains the critical parts...
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Article
CREB antisense oligonucleotides induce non-apoptotic cell death in proliferating leukemia cells, but not normal hematopoietic cells, by a bizarre non-antisense mechanism
We report that antisense phosphorothioate oligodeoxyribonucleotides (PS-ODNs) against cyclic AMP response element-binding protein (CREB) induce the death of human leukemia cell lines including HL-60, Kasumi-1 ...
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Article
Radiation-induced vesico-vaginal fistula successfully repaired using a gracilis myocutaneous flap
Surgical repair of a radiation-induced vesico-vaginal fistula by a simple closure technique is extremely difficult. Here, we report a patient with a radiation-induced vesico-vaginal fistula that was successfu...
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Article
Tetralogy of Fallot with Levoatrial Cardinal Vein
A levoatrial cardinal vein is a rare congenital anomaly of the systemic veins. It is frequently associated with left-side obstructive anomalies. We report a case of tetralogy of Fallot with a levoatrial cardin...
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A clinico-pathological study of cervical myelopathy in rheumatoid arthritis: post-mortem analysis of two cases
Two patients who developed cervical myelopathy secondary to rheumatoid arthritis were analyzed post mortem. One patient had anterior atlanto-axial subluxation (AAS) combined with subaxial subluxation (SS), an...
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Article
Pathological fracture of a lumbar vertebra caused by rheumatoid arthritis – a case report
We describe a case of rheumatoid arthritis (RA) with collapse of the L3 lumbar vertebra for which surgery was performed. The pathogenesis of lumbar lesions affected by RA is discussed and the literature reviewed
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Article
Relationship between calculated carboplatin area under the curve, using the Cockcroft-Calvert formula and the Chatelut formula, and thrombocytopenia induced by intraperitoneal carboplatin in combination with intravenous cyclophosphamide
Background. There is no standard formula to estimate doses for the intraperitoneal (IP) administration of carboplatin. We evaluated a combination of the Cockcroft and the Calvert (Cockcro...
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Article
Effect of the exposure dose of etoposide on the cell growth and cell kinetics of human ovarian cancer cells
Although schedule-dependent cytotoxicity of etoposide has been reported, its mechanisms have not been elucidated fully. In this study, we attempted to clarify what concentration, time or exposure dose (ED, co...
