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  1. No Access

    Article

    Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells

    Oncolytic adenoviruses are a promising tool in cancer therapy. In this study, we characterized the role of autophagy in oncolytic adenovirus-induced therapeutic effects. OBP-405, an oncolytic adenovirus regula...

    T Yokoyama, E Iwado, Y Kondo, H Aoki, Y Hayashi, M M Georgescu, R Sawaya… in Gene Therapy (2008)

  2. No Access

    Article

    A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo

    Signal transducer and activator of transcription-3 (STAT3) is constitutively activated in a variety of cancer types, including malignant gliomas. STAT3 is activated by phosphorylation of a tyrosine residue, af...

    A Iwamaru, S Szymanski, E Iwado, H Aoki, T Yokoyama, I Fokt, K Hess, C Conrad… in Oncogene (2007)

  3. No Access

    Article

    Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells

    The mammalian target of rapamycin (mTOR) plays a central role in regulating the proliferation of malignant glioma cells, and mTOR-specific inhibitors such as rapamycin analogs are considered as promising thera...

    A Iwamaru, Y Kondo, E Iwado, H Aoki, K Fujiwara, T Yokoyama, G B Mills, S Kondo in Oncogene (2007)

  4. No Access

    Article

    Ionizing radiation induces apoptosis and inhibits neuronal differentiation in rat neural stem cells via the c-Jun NH2-terminal kinase (JNK) pathway

    A substantial number of neural stem cells (NSCs) continue to proliferate and generate neurons in the central nervous system throughout life. Ionizing radiation, an important adjuvant therapy for glioma patient...

    T Kanzawa, E Iwado, H Aoki, A Iwamaru, E F Hollingsworth, R Sawaya, S Kondo… in Oncogene (2006)