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Article
Open AccessDeep history of cultural and linguistic evolution among Central African hunter-gatherers
Human evolutionary history in Central Africa reflects a deep history of population connectivity. However, Central African hunter-gatherers (CAHGs) currently speak languages acquired from their neighbouring far...
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Article
Open AccessMexican Biobank advances population and medical genomics of diverse ancestries
Latin America continues to be severely underrepresented in genomics research, and fine-scale genetic histories and complex trait architectures remain hidden owing to insufficient data1. To fill this gap, the Mexi...
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Article
Open AccessNeural ADMIXTURE for rapid genomic clustering
Characterizing the genetic structure of large cohorts has become increasingly important as genetic studies extend to massive, increasingly diverse biobanks. Popular methods decompose individual genomes into fr...
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Article
Opportunities and challenges for the use of common controls in sequencing studies
Genome-wide association studies using large-scale genome and exome sequencing data have become increasingly valuable in identifying associations between genetic variants and disease, transforming basic researc...
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Article
Open AccessDeconvoluting complex correlates of COVID-19 severity with a multi-omic pandemic tracking strategy
The SARS-CoV-2 pandemic has differentially impacted populations across race and ethnicity. A multi-omic approach represents a powerful tool to examine risk across multi-ancestry genomes. We leverage a pandemic...
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Article
Paths and timings of the peopling of Polynesia inferred from genomic networks
Polynesia was settled in a series of extraordinary voyages across an ocean spanning one third of the Earth1, but the sequences of islands settled remain unknown and their timings disputed. Currently, several cent...
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Article
Native American gene flow into Polynesia predating Easter Island settlement
The possibility of voyaging contact between prehistoric Polynesian and Native American populations has long intrigued researchers. Proponents have pointed to the existence of New World crops, such as the sweet...