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Article
Open AccessTargeting FLT3-TAZ signaling to suppress drug resistance in blast phase chronic myeloid leukemia
Although the development of BCR::ABL1 tyrosine kinase inhibitors (TKIs) rendered chronic myeloid leukemia (CML) a manageable condition, acquisition of drug resistance during blast phase (BP) progression remain...
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Article
Open AccessOverlooked KCNQ4 variants augment the risk of hearing loss
Pathogenic variants of KCNQ4 cause symmetrical, late-onset, progressive, high-frequency-affected hearing loss, which eventually involves all frequencies with age. To understand the contribution of KCNQ4 variants ...
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Article
Co-existence of a novel translocation t(11;22)(q23;q12.1) with PML-RARA in acute promyelocytic leukemia: a case report
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Article
COCH-related autosomal dominant nonsyndromic hearing loss: a phenotype–genotype study
This phenotype–genotype study aimed to investigate the extent of audioprofile variability related to cochlin major domains and to identify potential ethnic-specific differences associated with COCH-related hearin...
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Article
Open AccessDifferential genetic diagnoses of adult post-lingual hearing loss according to the audiogram pattern and novel candidate gene evaluation
Ski-slope hearing loss (HL), which refers to increased auditory threshold at high frequencies, is common in adults. However, genetic contributions to this post-lingual HL remain largely unknown. Here, we prosp...
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Article
Open AccessA novel bi-alleleic DDX41 mutations in B-cell lymphoblastic leukemia: case report
The germline mutations of DDX41, also known as DEAD box RNA helicase 41, have been found in about 1.5% of myeloid neoplasms (MNs). Development of MDS/AML is relatively common in germline DDX41 mutations. However,...
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Article
The cytotoxicity and skin irritation of nanostructured cellulose surface fabricated by a plasma-induced method
Applications of nano-sized cellulose, such as use in tissue bio-scaffolds and drug delivery, have gained much attention in medical research. However, there are only a few studies reporting the skin toxicity of...
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Article
Open AccessMolecular diagnosis of hereditary spherocytosis by multi-gene target sequencing in Korea: matching with osmotic fragility test and presence of spherocyte
Current diagnostic tests for hereditary spherocytosis (HS) focus on the detection of hemolysis or indirectly assessing defects of membrane protein, whereas direct methods to detect protein defects are complica...
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Article
Open AccessnArgBP2-SAPAP-SHANK, the core postsynaptic triad associated with psychiatric disorders
Despite the complex genetic architecture, a broad spectrum of psychiatric disorders can still be caused by mutation(s) in the same gene. These disorders are interrelated with overlap** causative mechanisms i...
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Article
Open AccessEndosome-mediated endocytic mechanism replenishes the majority of synaptic vesicles at mature CNS synapses in an activity-dependent manner
Whether synaptic vesicles (SVs) are recovered via endosome-mediated pathways is a matter of debate; however, recent evidence suggests that clathrin-independent bulk endocytosis (CIE) via endosomes is functiona...
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Article
Open AccessShort telomere length and its correlation with gene mutations in myelodysplastic syndrome
Telomere erosion can lead to genomic instability and cancer progression. It has been suggested that the shortest telomere, not the average telomere length (TL), is critical for cell viability. Some studies hav...
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Chapter and Conference Paper
R&D Project Management Using Context in Document: Research Descriptor
Recently developed requirement management tools or configuration management tools identify the requests within the project and offer traceability for the configuration items related to requests throughout the ...
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Chapter and Conference Paper
Research Descriptor Based Project Management Approach for R&D Projects
R&D projects, unlike existing System Integration (SI) projects or software development projects, are ambiguous in their goal or the resolution methods in order to reach that goal. It also has limits in having ...
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Article
Characterization of a complete genome of a circular single-stranded DNA virus from porcine stools in Korea
Porcine circular single-stranded DNA viruses have been just identified from swine feces in Korea. This virus was mentioned as bovine stool-associated circular DNA virus (BoSCV)-like virus discovered from porci...
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Article
Open AccessThe application of an in situ karyoty** technique for mesenchymal stromal cells: a validation and comparison study with classical G-banding
The cytogenetic analysis of mesenchymal stromal cells (MSCs) is essential for verifying the safety and stability of MSCs. An in situ technique, which uses cells grown on coverslips for karyoty** and minimizes c...
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Article
A possible role of STRA8 as a transcriptional factor
The Stra8 gene is a retinoic acid responsive gene. Its expression in premeiotic germ cells in both sexes implies that STRA8 protein plays roles for the progression of meiosis. Stra8 deficient germ cells do not in...
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Article
Synthesis of single phase aragonite precipitated calcium carbonate in Ca(OH)2-Na2CO3-NaOH reaction system
The formation behavior of precipitated calcium carbonate polymorphs was investigated in three different supersaturation levels. Because the most easily adjustable and influential variable determining supersatu...
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Article
Open AccessDetection of circulating tumor cells in patients with gastrointestinal tract cancer using RT-PCR and its clinical implications
To investigate the relationship between the presence of circulating tumor cells in different stages of gastrointestinal tract cancer and the subsequent relapse or distant metastasis, circulating levels of CEA ...
