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Article
Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo
Lipid nanoparticles (LNPs) are widely used for mRNA delivery, with cationic lipids greatly affecting biodistribution, cellular uptake, endosomal escape and transfection efficiency. However, the laborious synth...
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Article
Open AccessCorrection: Anti-lymphangiogenesis for boosting drug accumulation in tumors
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Article
Open AccessAnti-lymphangiogenesis for boosting drug accumulation in tumors
The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an even more significant concern in the clinical prospects for nanomedicines. Various str...
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Article
Open AccessHigh-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models
Lipid nanoparticles for delivering mRNA therapeutics hold immense promise for the treatment of a wide range of lung-associated diseases. However, the lack of effective methodologies capable of identifying the ...
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Article
Open AccessIn situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors
The ionizable lipidoid is a key component of lipid nanoparticles (LNPs). Degradable lipidoids containing extended alkyl branches have received tremendous attention, yet their optimization and investigation are...
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Article
Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines
Lipid nanoparticle (LNP)-formulated messenger RNA (mRNA) vaccineare a promising platform to prevent infectious diseases as demonstrated by the recent success of SARS-CoV-2 mRNA vaccines. To avoid immune recogn...
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Article
The adsorption mechanism of sludge-based biochar toward highly concentrated organic membrane concentrates from landfill leachate
In this study, the sludge-based biochar (BC) was prepared by dewatered sludge from a membrane bioreactor to treat the membrane concentrate. Then, the adsorbed and saturated BC was regenerated (RBC) by pyrolysi...
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Article
Concentration, sources, influencing factors and hazards of heavy metals in indoor and outdoor dust: A review
Heavy metals are a common class of toxic contaminants in soil, water and air, yet their occurrence in indoor environments is less known. Heavy metals enter people's bodies through ingestion, inhalation and der...
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Article
Improvement of low-temperature NH3-SCR catalytic activity over Mn-Ce oxide catalysts supported on sewage sludge char activated with KOH and H3PO4
Pyrolysis is a very potential sludge treatment technology that is low-cost and environmentally friendly; particularly, the pyrolysis sewage sludge char (SC) can be used as a catalyst support To improve the NO ...
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Article
Combination of tumour-infarction therapy and chemotherapy via the co-delivery of doxorubicin and thrombin encapsulated in tumour-targeted nanoparticles
Drugs that induce thrombosis in the tumour vasculature have not resulted in long-term tumour eradication owing to tumour regrowth from tissue in the surviving rim of the tumour, where tumour cells can derive n...
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Article
Open AccessMood contagion of robot body language in human robot interaction
The aim of our work is to design bodily mood expressions of humanoid robots for interactive settings that can be recognized by users and have (positive) effects on people who interact with the robots. To this ...
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Chapter and Conference Paper
An Approach to Navigation for the Humanoid Robot Nao in Domestic Environments
Humanoid robot navigation in domestic environments remains a challenging task. In this paper, we present an approach for navigating such environments for the humanoid robot Nao. We assume that a map of the env...
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Article
Experimental investigation on noise of cavitation nozzle and its chaotic behaviour
The researches of cavitation noise mainly focus on the incipiency and develo** of cavitation to prevent the cavititation erosion in the hydraulic machinery, while there is few report about the collapse stren...
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Chapter and Conference Paper
Bodily Mood Expression: Recognize Moods from Functional Behaviors of Humanoid Robots
Our goal is to develop bodily mood expression that can be used during the execution of functional behaviors for humanoid social robots. Our model generates such expression by stylizing behaviors through modula...
