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Open AccessThe catalytic role of the M2 metal ion in PP2Cα
PP2C family phosphatases (the type 2C family of protein phosphatases; or metal-dependent phosphatase, PPM) constitute an important class of signaling enzymes that regulate many fundamental life activities. All...
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Open AccessCadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site
The heavy metal cadmium is a non-degradable pollutant. By screening the effects of a panel of metal ions on the phosphatase activity, we unexpectedly identified cadmium as a potent inhibitor of PPM1A and PPM1G...
