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Open AccessGasless robot-assisted transaxillary hemithyroidectomy (RATH): learning curve and complications
Gasless robot-assisted transaxillary hemithyroidectomy (RATH) is regarded as an alternative surgical option for thyroid operations. However, the associated steep learning curve is a clinical concern. This stud...
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Open AccessGut microbes exacerbate systemic inflammation and behavior disorders in neurologic disease CADASIL
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a cerebral small vessel disease that carries mutations in NOTCH3. The clinical manifestations are influenced...
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Article
TriView-ParNet: parallel network for hybrid recognition of touching printed and handwritten strings based on feature fusion and three-view co-training
Deep learning has been a mainstream solution for recognizing printed and isolated handwritten characters in Optical Characters Recognition (OCR). However, it is still a challenge to hybrid recognition of adjoi...
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Open AccessAtypical haemolytic uremic syndrome with refractory multiorgan involvement and heterozygous CFHR1/CFHR3 gene deletion
We present this challenging case report of Atypical Haemolytic Uremic Syndrome (aHUS) presenting with multi-organ involvement in a patient and heterozygous CFHR1/CFHR3 gene variant, which was refractory to ini...
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Article
Multi-functional phase change materials with anti-liquid leakage, shape memory, switchable optical transparency and thermal energy storage
Multi-functional polymer gel materials based on thermal phase change materials (PCMs) are rapidly advancing the application of thermal energy storage (TES) in energy-saving buildings. In this work, we report m...
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Advanced bamboo composite materials with high-efficiency and long-term anti-microbial fouling performance
Renewable bamboo materials have broad application prospects in the fields of structural construction, insulation and acoustic management due to their multi-layer porous structure, attractive directional layout...
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Article
Open Accessαvβ3-targeted sEVs for efficient intracellular delivery of proteins using MFG-E8
Small extracellular vesicles (sEVs) are nanometer-sized membranous particles shed by many types of cells and can transfer a multitude of cargos between cells. Recent studies of sEVs have been focusing on their...
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Open AccessIntranasal HD-Ad vaccine protects the upper and lower respiratory tracts of hACE2 mice against SARS-CoV-2
The ongoing COVID-19 pandemic has resulted in 185 million recorded cases and over 4 million deaths worldwide. Several COVID-19 vaccines have been approved for emergency use in humans and are being used in many...
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Article
Open AccessYTHDF1 promotes the proliferation, migration, and invasion of prostate cancer cells by regulating TRIM44
Prostate cancer (PCa) is one of the most common malignancies in men. YTHDF1 may play an important role in promoting PCa progression, but there is no reports to date on YTHDF1 function in PCa.
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Article
Dyed bamboo composite materials with excellent anti-microbial corrosion
Bamboo, as a potential ecological building material, has attracted a lot of attention, due to its wide distribution, more than 1000 species, short growth cycle of 3–5 years, three times the carbon dioxide adso...
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Article
Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline
Tuberculosis—the world’s leading cause of death by infectious disease—is increasingly resistant to current first-line antibiotics1. The bacterium Mycobacterium tuberculosis (which causes tuberculosis) can survive...
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Article
Open AccessTumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages
Immunosuppressive tumor microenvironment (TME) and ascites-derived spheroids in ovarian cancer (OC) facilitate tumor growth and progression, and also pose major obstacles for cancer therapy. The molecular path...
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Investigation of parameters that determine Nano-DC vaccine transport
Effective migration of dendritic cells into the lymphatic system organs is the prerequisite for a functional dendritic cell vaccine. We have previously developed a porous silicon microparticle (PSM)-based ther...
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Open AccessSensitizing non-small cell lung cancer to BCL-xL-targeted apoptosis
Lung cancer is the leading cause of death in the United States, with non-small cell lung cancers (NSCLC) accounting for 85% of all cases. By analyzing the expression profile of the pro-apoptotic and anti-apopt...
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Article
An injectable nanoparticle generator enhances delivery of cancer therapeutics
A silicon-based microparticle that delivers doxorubicin nanoparticles improves the efficacy of breast cancer chemotherapy.
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Polymorphism in interleukin 21 gene is associated with decreased susceptibility to diffuse large B cell lymphoma
Interleukin 21 (IL-21) plays a key role in innate and adaptive immunity. Polymorphisms in IL-21 gene may be greatly involved in various diseases. The aim of the study was to investigate the association between...
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Article
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
This study finds that triple-negative breast cancers (TNBC) show an increased basal level of endoplasmic reticulum stress and activation of the XBP1 branch of the unfolded protein response; furthermore, XBP1 p...
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Article
RAFTsomes Containing Epitope-MHC-II Complexes Mediated CD4+ T Cell Activation and Antigen-Specific Immune Responses
To develop a liposome formulation incorporating antigen-presenting cells (APCs) membrane microdomains with enriched epitope/MHC complexes to evaluate the activities of these liposomes (RAFTsomes) to activate T...
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Article
Molecular characterization and expression analysis of elongation factors 1A and 2 from the Pacific white shrimp, Litopenaeus vannamei
Elongation factors (EF) are abundant cell proteins that play important roles in the metabolism of all multicellular organisms. Here we describe a functional analysis of elongation factor 1-alpha (EF1A) and elo...
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A microfabricated platform probing cytoskeleton dynamics using multidirectional topographical cues
Cell migration, which involves complicated coordination of cytoskeleton elements and regulatory molecules, plays a central role in a large variety of biological processes from development, immune response to t...
