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  1. Article

    Open Access

    Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages

    Immunosuppressive tumor microenvironment (TME) and ascites-derived spheroids in ovarian cancer (OC) facilitate tumor growth and progression, and also pose major obstacles for cancer therapy. The molecular path...

    Mei Song, Oladapo O. Yeku, Sarwish Rafiq, Terence Purdon, Xue Dong… in Nature Communications (2020)

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  2. Article

    Investigation of parameters that determine Nano-DC vaccine transport

    Effective migration of dendritic cells into the lymphatic system organs is the prerequisite for a functional dendritic cell vaccine. We have previously developed a porous silicon microparticle (PSM)-based ther...

    **gxin Zhang, Junhua Mai, Feng Li, Jianliang Shen… in Biomedical Microdevices (2019)

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  3. Article

    Open Access

    Sensitizing non-small cell lung cancer to BCL-xL-targeted apoptosis

    Lung cancer is the leading cause of death in the United States, with non-small cell lung cancers (NSCLC) accounting for 85% of all cases. By analyzing the expression profile of the pro-apoptotic and anti-apopt...

    Qi Shen, Jun Li, Junhua Mai, Zhe Zhang, Andrew Fisher, **aoyan Wu… in Cell Death & Disease (2018)

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  4. No Access

    Article

    An injectable nanoparticle generator enhances delivery of cancer therapeutics

    A silicon-based microparticle that delivers doxorubicin nanoparticles improves the efficacy of breast cancer chemotherapy.

    Rong Xu, Guodong Zhang, Junhua Mai, **aoyong Deng… in Nature Biotechnology (2016)

  5. No Access

    Article

    XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

    This study finds that triple-negative breast cancers (TNBC) show an increased basal level of endoplasmic reticulum stress and activation of the XBP1 branch of the unfolded protein response; furthermore, XBP1 p...

    ** Chen, Dimitrios Iliopoulos, Qing Zhang, Qianzi Tang, Matthew B. Greenblatt… in Nature (2014)

  6. No Access

    Article

    RAFTsomes Containing Epitope-MHC-II Complexes Mediated CD4+ T Cell Activation and Antigen-Specific Immune Responses

    To develop a liposome formulation incorporating antigen-presenting cells (APCs) membrane microdomains with enriched epitope/MHC complexes to evaluate the activities of these liposomes (RAFTsomes) to activate T...

    Qian Ding, Jian Chen, **aohui Wei, Wenqiang Sun, Junhua Mai… in Pharmaceutical Research (2013)