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Article
Overall haemostatic potential assay for prediction of outcomes in venous and arterial thrombosis and thrombo-inflammatory diseases
Thromboembolic diseases including arterial and venous thrombosis are common causes of morbidity and mortality globally. Thrombosis frequently recurs and can also complicate many inflammatory conditions through...
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Article
Open AccessThe Natural History and Risk Factors for the Development of Food Allergies in Children and Adults
This narrative review explores food allergy prevalence and natural history stratified by life stages, especially in context of evolving knowledge over the last few decades.
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Article
Open AccessCurrent challenges in the prevention and management of post-thrombotic syndrome—towards improved prevention
Post-thrombotic syndrome (PTS) is a common and potentially debilitating complication of deep vein thrombosis (DVT), affecting up to 50% of DVT patients. The consequence of this chronic condition includes reduc...
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Article
Disparities in the Diagnosis and Management of Anaphylaxis
The goal of this review is to characterize health disparities impacting the recognition and treatment of anaphylaxis.
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Article
Open AccessOverall haemostatic potential (OHP) assay can risk stratify for venous thromboembolism recurrence in anticoagulated patients
Assessing the risk of recurrent venous thromboembolism (VTE), particularly when patients are anticoagulated, remains a major challenge largely due to the lack of biomarkers. Blood was sampled from adult VTE pa...
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Article
Open AccessLaboratory markers of severity across three COVID-19 outbreaks in Australia: has Omicron and vaccinations changed disease presentation?
COVID-19 has rapidly evolved since it was first discovered in December 2019. We aimed to retrospectively review our experience with COVID-19 infection across 2020–2022, focusing on differences in laboratory ma...
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Article
TGF-β-induced CD4+ FoxP3+ regulatory T cell-derived extracellular vesicles modulate Notch1 signaling through miR-449a and prevent collagen-induced arthritis in a murine model
CD4+FOXP3+ Treg cells are central to the maintenance of self-tolerance and can be defective in autoimmunity. In autoimmune rheumatic diseases, dysfunctional self-tolerance, is to a large extent, caused by insuffi...
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Article
Retrospective review of d-dimer testing for venous thrombosis recurrence risk stratification: is this a useful test in the real world?
Predicting the risk of recurrence after venous thromboembolism (VTE) remains an important clinical challenge. Post-anticoagulation cessation d-dimer has previously been shown to be associated with increased VTE r...
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Article
Open AccessHigh salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways
The increased incidence of systemic lupus erythematosus (SLE) in recent decades might be related to changes in modern dietary habits. Since sodium chloride (NaCl) promotes pathogenic T cell responses, we hypot...
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Chapter
Anaphylaxis Education: For Patients, Daycares, Schools, and Colleges
Anaphylaxis, a medical emergency which may be triggered by food, venom sting, medication, or exercise, occurs at daycares, schools, or colleges. Anaphylaxis can develop in students with known allergies, but fi...
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Chapter
Management of Food Allergy in the School Setting: The Clinician’s Role
Primary care and pediatric specialists participate in managing school-age children with food allergies. The pillars of food allergy management are prevention of and emergency preparedness to manage allergic re...
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Chapter
Oral Immunotherapy (OIT)
Currently, there is no approved therapy for food allergies. Thus, treatment strategies are limited to avoidance of the allergic food and having emergency treatment available for reactions. An increasing amount...
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Article
Could This Be IT? Epicutaneous, Sublingual, and Subcutaneous Immunotherapy for the Treatment of Food Allergies
Over the last decade, there has been a spark in innovation in the development of therapies for food allergy. Herein, we describe the background and recent advances for food-specific immunotherapies including e...
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Article
Open AccessAll trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling
Regulation of neural inflammation is considered as a vital therapeutic target in ischemic stroke. All-trans retinoic acid (atRA), a potent immune modulator, has raised interest in the field of stroke therapy. ...
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Article
Open AccessA preclinical study—systemic evaluation of safety on mesenchymal stem cells derived from human gingiva tissue
Mounting evidence has shown that a novel subset of mesenchymal stem cells (MSCs) derived from human gingiva referred to as gingival mesenchymal stem cells (GMSCs) displays a greater immunotherapeutic potential...
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Article
Open AccessDifferential roles of TNFα-TNFR1 and TNFα-TNFR2 in the differentiation and function of CD4+Foxp3+ induced Treg cells in vitro and in vivo periphery in autoimmune diseases
Tumor Necrosis Factor (TNF) α is a multifunctional cytokine with pro-inflammatory and anti-inflammatory characteristics. Increasing evidence suggests that thymus-derived, natural regulatory T cells (nTreg) exp...
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Article
Enhancing the Safety and Efficacy of Food Allergy Immunotherapy: a Review of Adjunctive Therapies
Food allergy is a potentially life-threatening condition with no approved curative therapy. A number of food allergen immunotherapies are being investigated in phase II/III trials; however, these are limited i...
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Article
Open AccessParent perspectives on school food allergy policy
Food allergy affects up to 8% of children in the U.S. There is minimal research to date on food allergy policies that are currently in place in schools and the opinions of parents of children with food allergy...
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Article
3D-printed soft-tissue physical models of renal malignancies for individualized surgical simulation: a feasibility study
To construct patient-specific physical three-dimensional (3D) models of renal units with materials that approximates the properties of renal tissue to allow pre-operative and robotic training surgical simulati...
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Article
A protocol to develop T helper and Treg cells in vivo
