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  1. No Access

    Article

    Improved methods for testing antiresorptive compounds in human osteoclast cultures

    We cultured human bone marrow-derived stem cells on bovine bone slices in 96-well plates in the presence of M-CSF and RANKL, allowing them to differentiate into osteoclasts. Secreted TRACP 5b was a useful endp...

    Jukka P. Rissanen, Hannele Ylipahkala… in Journal of Bone and Mineral Metabolism (2009)

  2. No Access

    Article

    Secreted Tartrate-Resistant Acid Phosphatase 5b is a Marker of Osteoclast Number in Human Osteoclast Cultures and the Rat Ovariectomy Model

    To study the effects of estrogen withdrawal on osteoclast number and osteoclast activity in the rat ovariectomy (OVX) model.

    Jukka P. Rissanen, Mari I. Suominen, Zhiqi Peng… in Calcified Tissue International (2008)

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    Article

    Short-Term Changes in Serum PINP Predict Long-Term Changes in Trabecular Bone in the Rat Ovariectomy Model

    Serum procollagen I N-terminal propeptide (PINP) is a sensitive bone formation marker in humans. We have developed a nonradioactive immunoassay for rat PINP and studied PINP as a bone formation marker in the r...

    Jukka P. Rissanen, Mari I. Suominen, Zhiqi Peng… in Calcified Tissue International (2008)