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    Improved methods for testing antiresorptive compounds in human osteoclast cultures

    We cultured human bone marrow-derived stem cells on bovine bone slices in 96-well plates in the presence of M-CSF and RANKL, allowing them to differentiate into osteoclasts. Secreted TRACP 5b was a useful endp...

    Jukka P. Rissanen, Hannele Ylipahkala… in Journal of Bone and Mineral Metabolism (2009)