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  1. Article

    Open Access

    Induction of CD73 prevents death after emergency open aortic surgery for a ruptured abdominal aortic aneurysm: a randomized, double-blind, placebo-controlled study

    Mortality remains high after emergency open surgery for a ruptured abdominal aortic aneurysm (RAAA). The aim of the present study was to assess, if intravenous (IV) Interferon (IFN) beta-1a improve survival af...

    Harri Hakovirta, Juho Jalkanen, Eija Saimanen, Tiia Kukkonen in Scientific Reports (2022)

  2. Article

    Open Access

    Red blood cell transfusion induces abnormal HIF-1α response to cytokine storm after adult cardiac surgery

    Patients undergoing cardiac surgery develop a marked postoperative systemic inflammatory response. Blood transfusion may contribute to disruption of homeostasis in these patients. We sought to evaluate the imp...

    Emma Viikinkoski, Juho Jalkanen, Jarmo Gunn, Tuija Vasankari in Scientific Reports (2021)

  3. Article

    Open Access

    Hypoxia-induced inflammation and purinergic signaling in cross clam** the human aorta

    Open aortic surgery evokes a systemic inflammatory response and is associated with high morbidity and mortality. Purinergic signaling has been shown to be crucial for maintaining vascular integrity and attenu...

    Juho Jalkanen, Mikael Maksimow, Sirpa Jalkanen, Harri Hakovirta in SpringerPlus (2016)