12 Result(s)
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Open AccessPredicting the severity of postoperative scars using artificial intelligence based on images and clinical data
Evaluation of scar severity is crucial for determining proper treatment modalities; however, there is no gold standard for assessing scars. This study aimed to develop and evaluate an artificial intelligence m...
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Open AccessRecellularized lymph node scaffolds with human adipose-derived stem cells enhance lymph node regeneration to improve lymphedema
To overcome the limitations of lymphedema treatment, human adipose-derived stem cells (hADSCs) were injected into decellularized lymph nodes to produce a recellularized lymph node-scaffold, and the effect of l...
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Article
Non-epitaxial single-crystal 2D material growth by geometric confinement
Two-dimensional (2D) materials and their heterostructures show a promising path for next-generation electronics1–3. Nevertheless, 2D-based electronics have not been commercialized, owing mainly to three critical ...
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Article
Open AccessA biomimetic ocular prosthesis system: emulating autonomic pupil and corneal reflections
The human light modulation response allows humans to perceive objects clearly by receiving the appropriate amount of light from the environment. This paper proposes a biomimetic ocular prosthesis system that m...
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Open AccessPhysician adherence and patient-reported outcomes in heart failure with reduced ejection fraction in the era of angiotensin receptor-neprilysin inhibitor therapy
This Korean nationwide, multicenter, noninterventional, prospective cohort study aimed to analyze physician adherence to guideline-recommended therapy for heart failure (HF) with reduced ejection fraction (HFr...
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Open AccessInhibition of Wnt signaling pathway suppresses radiation-induced dermal fibrosis
Progressive fibrosis of the dermal tissues is a challenging complication of radiotherapy whose underlying mechanism is not fully understood, and there are few available treatments. The canonical Wnt/β-catenin ...
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Open AccessSingle cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches
Stomach and intestinal stem cells are located in discrete niches called the isthmus and crypt, respectively. Recent studies have demonstrated a surprisingly conserved role for Wnt signaling in gastrointestinal...
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Open AccessThermogenesis-independent metabolic benefits conferred by isocaloric intermittent fasting in ob/ob mice
Intermittent fasting (IF) is an effective dietary intervention to counteract obesity-associated metabolic abnormalities. Previously, we and others have highlighted white adipose tissue (WAT) browning as the ma...
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Open AccessProfibrogenic effect of high-mobility group box protein-1 in human dermal fibroblasts and its excess in keloid tissues
High-mobility group box 1 (HMGB1) protein acts as a DNA chaperone for nuclear homeostasis. It translocates into the cytosol and is secreted into extracellular spaces, triggering proinflammatory cytokines and a...
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Open AccessReduced oxidative capacity in macrophages results in systemic insulin resistance
Oxidative functions of adipose tissue macrophages control the polarization of M1-like and M2-like phenotypes, but whether reduced macrophage oxidative function causes systemic insulin resistance in vivo is not...
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Open AccessDecoy Wnt receptor (sLRP6E1E2)-expressing adenovirus induces anti-fibrotic effect via inhibition of Wnt and TGF-β signaling
Aberrant activation of the canonical Wingless type (Wnt) signaling pathway plays a key role in the development of hypertrophic scars and keloids, and this aberrant activation of Wnt pathway can be a potential ...
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Article
Obesity-associated variants within FTO form long-range functional connections with IRX3
Obesity-associated noncoding sequences within FTO are functionally connected with IRX3, and long-range enhancers in this region recapitulate aspects of IRX3 expression, suggesting that the obesity-associated inte...
