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Article
Open AccessEffect of gut microbiota-derived metabolites and extracellular vesicles on neurodegenerative disease in a gut-brain axis chip
A new perspective suggests that a dynamic bidirectional communication system, often referred to as the microbiome-gut-brain axis, exists among the gut, its microbiome, and the central nervous system (CNS). Thi...
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Article
Open AccessThe short-term effect of ambient particulate matter on suicide death
Air pollution can cause various respiratory and neurological diseases and continuous exposure can lead to death. Previous studies have reported that particulate matter (PM) exposure increases the risk of depre...
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Article
Functional Brain Networks to Evaluate Treatment Responses in Parkinson’s Disease
Network analysis of functional brain scans acquired with [18F]-fluorodeoxyglucose positron emission tomography (FDG PET, to map cerebral glucose metabolism), or resting-state functional magnetic resonance imaging...
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Article
Open AccessThe clinical effectiveness of fused image of single-photon emission CT and facial CT for the evaluation of degenerative change of mandibular condylar head
The primary objective of this study was to assess the clinical effectiveness of fused images obtained from single-photon emission computed tomography (SPECT) and facial computed tomography (CT) for evaluating ...
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Article
Open AccessGenomic and evolutionary characteristics of metastatic gastric cancer by routes
In gastric cancer (GC) patients, metastatic progression through the lymphatic, hematogenous, peritoneal, and ovarian routes, is the ultimate cause of death. However, the genomic and evolutionary characteristic...
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Open AccessAuthor Correction: Clinical molecular subty** reveals intrinsic mesenchymal reprogramming in gastric cancer cells
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Open AccessClinical molecular subty** reveals intrinsic mesenchymal reprogramming in gastric cancer cells
The mesenchymal cancer phenotype is known to be clinically related to treatment resistance and a poor prognosis. We identified gene signature-based molecular subtypes of gastric cancer (GC, n = 547) based on tran...
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Article
Open AccessEffect of gut microbiome-derived metabolites and extracellular vesicles on hepatocyte functions in a gut-liver axis chip
Metabolism, is a complex process involving the gut and the liver tissue, is difficult to be reproduced in vitro with conventional single cell culture systems. To tackle this challenge, we developed a gut-liver...
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Article
Open AccessHumanlike spontaneous motion coordination of robotic fingers through spatial multi-input spike signal multiplexing
With advances in robotic technology, the complexity of control of robot has been increasing owing to fundamental signal bottlenecks and limited expressible logic state of the von Neumann architecture. Here, we...
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Article
Open AccessA biomimetic ocular prosthesis system: emulating autonomic pupil and corneal reflections
The human light modulation response allows humans to perceive objects clearly by receiving the appropriate amount of light from the environment. This paper proposes a biomimetic ocular prosthesis system that m...
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Article
Scattering and clustering the proximal screw construct in unilateral locking plate osteosynthesis of distal femoral fractures
The importance of fixation construct in locking compression plate (LCP) is not well enlightened until recently. The aim of this study was to investigate radiological and clinical outcomes of scattering and clu...
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Article
Clinicopathologic and genomic characteristics of mucinous gastric adenocarcinoma
Mucinous gastric adenocarcinoma (MGC) is a rare but distinctive histologic subtype of gastric cancer (GC). The clinico-pathologic and genomic characteristics of MGC have not been well evaluated.
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Article
Prospective F-18 FDOPA PET Imaging Study in Human PD
We present the findings of our final prospective study submitted to the U.S. Food and Drug Administration (FDA) for New Drug Application (NDA) approval for the use of 3,4-dihydroxy-6-[18F]fluoro-l-phenylalanine (...
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Article
Open AccessA general fruit acid chelation route for eco-friendly and ambient 3D printing of metals
Recent advances in metal additive manufacturing (AM) have provided new opportunities for prompt designs of prototypes and facile personalization of products befitting the fourth industrial revolution. In this ...
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Article
Open AccessContributions of the microbiome to intestinal inflammation in a gut-on-a-chip
The intestinal microbiome affects a number of biological functions of the organism. Although the animal model is a powerful tool to study the relationship between the host and microbe, a physiologically releva...
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Article
Open AccessEffect of biochemical and biomechanical factors on vascularization of kidney organoid-on-a-chip
Kidney organoids derived from the human pluripotent stem cells (hPSCs) recapitulating human kidney are the attractive tool for kidney regeneration, disease modeling, and drug screening. However, the kidney org...
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Article
Neuropathological correlation supports automated image-based differential diagnosis in parkinsonism
Up to 25% of patients diagnosed as idiopathic Parkinson’s disease (IPD) have an atypical parkinsonian syndrome (APS). We had previously validated an automated image-based algorithm to discriminate between IPD,...
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Article
Open AccessPrevalence of cancer susceptibility variants in patients with multiple Lynch syndrome related cancers
Along with early-onset cancers, multiple primary cancers (MPCs) are likely resulting from increased genetic susceptibility; however, the associated predisposition genes or prevalence of the pathogenic variants...
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Article
Prominent hypointense vessel on susceptibility-weighted images accompanying hyperacute and acute large infarction
Multiple prominent hypointense vessels on susceptibility-weighted image (SWI) have been found in the ischemic territory of patients with acute ischemic stroke. SWI is suitable for venous imaging.
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Article
Open AccessCancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis
Targeted therapies for gastrointestinal stromal tumor (GIST) are modestly effective, but GIST cannot be cured with single agent tyrosine kinase inhibitors. In this study, we sought to identify new therapeutic ...
