52 Result(s)
within
José-Manuel Fernández-Real
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Reference Work Entry In depth
Gut Microbiome and Cognitive Functions in Metabolic Diseases
In recent years, there has been an increase in the study of metabolic illnesses and the gut microbiota. According to certain research, the pathogenesis and development of various metabolic illnesses, including...
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Article
Open AccessThe interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis
Dietary lipids can affect metabolic health through gut microbiota-mediated mechanisms, but the influence of lipid-microbiota interaction on liver steatosis is largely unknown. We investigate the impact of diet...
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Living Reference Work Entry In depth
Gut Microbiome and Cognitive Functions in Metabolic Diseases
In recent years, there has been an increase in the study of metabolic illnesses and the gut microbiota. According to certain research, the pathogenesis and development of various metabolic illnesses, including...
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Article
The role of iron in host–microbiota crosstalk and its effects on systemic glucose metabolism
Iron is critical for the appearance and maintenance of life on Earth. Almost all organisms compete or cooperate for iron acquisition, demonstrating the importance of this essential element for the biological a...
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Article
Open AccessOrally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate
Succinate is produced by both human cells and by gut bacteria and couples metabolism to inflammation as an extracellular signaling transducer. Circulating succinate is elevated in patients with obesity and typ...
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Reference Work Entry In depth
Calprotectin as a Biological Indicator in Nutrition
The inflammatory myeloid-related protein complex calprotectin, also known as MRP8/14, is a heterodimer comprised of two intracellular calcium-binding proteins, S100A8 (MRP8) and S100A9 (MRP14), predominantly e...
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Living Reference Work Entry In depth
Calprotectin as a Biological Indicator in Nutrition
The inflammatory myeloid-related protein complex calprotectin, also known as MRP8/14, is a heterodimer comprised of two intracellular calcium-binding proteins, S100A8 (MRP8) and S100A9 (MRP14), predominantly e...
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Article
Open AccessRegulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3
Dysfunction of adipocytes and adipose tissue is a primary defect in obesity and obesity-associated metabolic diseases. Interferon regulatory factor 3 (IRF3) has been implicated in adipogenesis. However, the ro...
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Article
Open AccessBMP8 and activated brown adipose tissue in human newborns
The classical dogma states that brown adipose tissue (BAT) plays a major role in the regulation of temperature in neonates. However, although BAT has been studied in infants for more than a century, the knowle...
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Article
Open AccessIron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome
The gut microbiome and iron status are known to play a role in the pathophysiology of non-alcoholic fatty liver disease (NAFLD), although their complex interaction remains unclear.
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Article
Factors associated with prolonged hospital stay after laparoscopic adrenalectomy
Laparoscopy is the standard technique for resecting adrenal tumors, but short-term outcomes such as length of stay (LOS) vary widely between centers. We aimed to identify factors associated with LOS after late...
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Article
Morbidly obese subjects show increased serum sulfide in proportion to fat mass
The importance of hydrogen sulfide is increasingly recognized in the pathophysiology of obesity and type 2 diabetes in animal models. Very few studies have evaluated circulating sulfides in humans, with discre...
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Article
Open AccessGut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
Gonadal steroid hormones have been suggested as the underlying mechanism responsible for the sexual dimorphism observed in metabolic diseases. Animal studies have also evidenced a causal role of the gut microb...
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Article
Open AccessGut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile
The chaperone ClpB, a bacterial protein, is a conformational antigen-mimetic of α-melanocyte-stimulating hormone (α-MSH) implicated in body weight regulation in mice. We here investigated the potential associa...
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Article
Consider the microbiome in the equation! They were here before us...and hosted us!
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Article
Microbiota impacts on chronic inflammation and metabolic syndrome - related cognitive dysfunction
Cognitive dysfunction, one of the major concerns of increased life expectancy, is prevalent in patients with metabolic disorders. Added to the inflammation in the context of aging (inflammaging), low-grade chr...
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Article
Open AccessAnalysis of miRNA signatures in CSF identifies upregulation of miR-21 and miR-146a/b in patients with multiple sclerosis and active lesions
MicroRNAs (miRNAs) have been reported as deregulated in active brain lesions derived from patients with multiple sclerosis (MS). In there, these post-transcriptional regulators may elicit very important effect...
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Article
Open AccessCentral nicotine induces browning through hypothalamic κ opioid receptor
Increased body weight is a major factor that interferes with smoking cessation. Nicotine, the main bioactive compound in tobacco, has been demonstrated to have an impact on energy balance, since it affects bot...
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Article
Adipose tissue TSH as a new modulator of human adipocyte mitochondrial function
Recent studies indicate a possible role of TSH/TSHR signalling axis on adipogenesis and adipose tissue physiology. Here, we aimed to investigate the relationship between adipose tissue TSHB and adipose tissue phy...
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Article
Glutamate interactions with obesity, insulin resistance, cognition and gut microbiota composition
To investigate the interactions among fecal and plasma glutamate levels, insulin resistance cognition and gut microbiota composition in obese and non-obese subjects.
