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Article
Association Between Paraoxonase Gene Polymorphisms and Intracerebral Hemorrhage in a Korean Population
The human paraoxonase (PON) gene family includes three members: PON1, PON2, and PON3. PON, which prevents the oxidative modification of lipoproteins, has been implicated as a potential risk factor of the cereb...
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Article
Protective Effect of Carbamazepine on Kainic Acid-induced Neuronal Cell Death Through Activation of Signal Transducer and Activator of Transcription-3
Studies have shown that the protective effect of carbamazepine (CBZ) on seizure-induced neuronal injury. However, its precise mechanisms remain unknown. Here, to investigate the neuroprotective mechanism of CB...
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Article
Association of Toll-like Receptor 2 Polymorphisms with National Institute of Health Stroke Scale Scores of Ischemic Stroke Patients
Toll-like receptor 2 (TLR2) has been shown to have an important role in the postischemic inflammatory response and to contribute to ischemic brain damage. In this study, we investigated whether coding region s...
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Article
Effect of Acupuncture on Hypothalamic–Pituitary–Adrenal System in Maternal Separation Rats
The maternal separation (MS) animal model has been widely used to study early life stress and several psychiatric conditions such as depression and anxiety. In this study, we investigated the effect of acupunc...
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Article
Association of Polymorphism in the Promoter of the Melatonin Receptor 1A Gene with Schizophrenia and with Insomnia Symptoms in Schizophrenia Patients
Schizophrenia patients commonly have sleep disturbances. In this study, we investigated whether single nucleotide polymorphisms (SNPs) in the promoter region of the melatonin receptor genes (MTNR1A and MTNR1B)...
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Article
Open AccessAssociation between polymorphisms of arachidonate 12-lipoxygenase (ALOX12) and schizophrenia in a Korean population
Arachidonic acid (AA), an essential polyunsaturated fatty acid, is one of the major components of neural membranes, which show an altered phospholipid composition in schizophrenia. Arachidonate 12-lipoxygenase (A...
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Article
Open AccessNo association between polymorphisms of WNT2and schizophrenia in a Korean population
Wingless-type MMTV integration site family member 2 (WNT2) has a potentially important role in neuronal development; however, there has yet to be an investigation into the association between single nucleotide...
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Article
Open AccessAssociation study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia
The occurrence of aberrant functional connectivity in the neuronal circuit is one of the integrative theories of the etiology of schizophrenia. Previous studies have reported that the protein and mRNA levels o...
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Article
Open AccessAngiotensin converting enzyme gene polymorphism in Korean patients with primary knee osteoarthritis
Angiotensin converting enzyme (ACE) plays an important role in the physiology of vasculature, blood pressure and inflammation. ACE gene, known to have insertion/deletion (I/D) polymorphism, has been widely inv...
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Article
Open AccessEvaluation of a Apo-1/Fas promoter polymorphism in Korean stroke patients
Apoptosis has been implicated in the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. Apo-1/Fas gene is one of the mediators of apoptosis in stroke. MvaI polymorphism is the f...