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Article
Open AccessOverlooked KCNQ4 variants augment the risk of hearing loss
Pathogenic variants of KCNQ4 cause symmetrical, late-onset, progressive, high-frequency-affected hearing loss, which eventually involves all frequencies with age. To understand the contribution of KCNQ4 variants ...
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Article
Bicarbonate permeation through anion channels: its role in health and disease
Many anion channels, frequently referred as Cl− channels, are permeable to different anions in addition to Cl−. As the second-most abundant anion in the human body, HCO3− permeation via anion channels has many im...
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Article
Open AccessTemperature-dependent increase in the calcium sensitivity and acceleration of activation of ANO6 chloride channel variants
Anoctamin-6 (ANO6) belongs to a family of calcium (Ca2+)-activated chloride channels (CaCCs), with three splicing variants (V1, V2, and V5) showing plasma membrane expression. Unlike other CaCCs, ANO6 requires a ...
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Article
Open AccessTrends in treatment during the last stages of life in end-stage gynecologic cancer patients who received active palliative chemotherapy: a comparative analysis of 10-year data in a single institution
Palliative chemotherapy should be used with caution when attempting to alleviate symptoms in patients with end-stage cancer. However, palliative chemotherapy continues to be utilized in cancer patients during ...
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Article
Investigation of hormone receptor expression and its prognostic value in endometrial stromal sarcoma
To evaluate the immunohistochemical (IHC) expression of hormone receptors and analyze the prognostic implication of these receptors in patients with endometrial stromal sarcoma (ESS). Fifty-one patients with E...
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Article
Open AccessThe efficacy of sentinel lymph node map** with indocyanine green in cervical cancer
Lymph node metastasis is a significant predictive factor for disease recurrence and survival in cervical cancer patients. Given the importance of lymph node metastasis, it is imperative that patients harboring...
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Article
Identification of critical amino acids in the proximal C-terminal of TREK-2 K+ channel for activation by acidic pHi and ATP-dependent inhibition
TWIK-related two-pore domain K+ channels (TREKs) are regulated by intracellular pH (pHi) and Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). Previously, Glu306 in proximal C-terminal (pCt) of mouse TREK-1 was ...
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Protocol
Prospective Clinical Correlation of the Histoculture Drug Response Assay for Ovarian Cancer
The histoculture drug response assay (HDRA) has been correlated clinically to a number of cancer types (please see Chaps. 7–11
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Article
Open AccessWAO International Scientific Conference (WISC 2016) Abstracts
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Article
Open AccessFeasibility of uterine preservation in the management of early-stage uterine adenosarcomas: a single institute experience
We aimed to evaluate the efficacy and the safety of uterine preservation in patients with early-stage uterine adenosarcoma who want to preserve future fertility.
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Article
Inhibition of TREK-2 K+ channels by PI(4,5)P2: an intrinsic mode of regulation by intracellular ATP via phosphatidylinositol kinase
TWIK-related two-pore domain K+ channels 1 and 2 (TREKs) are activated under various physicochemical conditions. However, the directions in which they are regulated by PI(4,5)P2 and intracellular ATP are not clea...
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Article
Open AccessXXIV World Allergy Congress 2015
A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts
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Article
Selective serotonin reuptake inhibitors facilitate ANO6 (TMEM16F) current activation and phosphatidylserine exposure
Anoctamin 6 (ANO6) is a member of the recently identified TMEM16/anoctamin protein family comprising Ca2+-activated Cl− channels that generate outward-rectifying ionic currents in response to intracellular Ca2+ i...
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Article
Laparoendoscopic single-site versus conventional laparoscopic-assisted vaginal hysterectomy for benign or pre-invasive uterine disease
The aim of this study was to compare the surgical outcomes of laparoendoscopic single-site (LESS) versus conventional laparoscopic-assisted vaginal hysterectomy (LAVH) in patients with benign or pre-invasive u...
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Reference Work Entry In depth
Immunohistochemistry as Biomarker Platform in Endometrial Cancer
Endometrial cancer is the most common malignancy of the female genital tract in Western countries, and its incidence is rapidly increasing in Asia. The standard treatment for women with endometrial cancer is s...
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Article
Gelidium amansii promotes dendritic spine morphology and synaptogenesis, and modulates NMDA receptor-mediated postsynaptic current
Neurotrophic factors are essential for the differentiation and maturation of develo** neurons as well as providing survival support to the mature neurons. Moreover, therapeutically neurotrophic factors are p...
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Article
Open AccessTransactivation of bad by vorinostat-induced acetylated p53 enhances doxorubicin-induced cytotoxicity in cervical cancer cells
Vorinostat (VOR) has been reported to enhance the cytotoxic effects of doxorubicin (DOX) with fewer side effects because of the lower DOX dosage in breast cancer cells. In this study, we investigated the novel...
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Living Reference Work Entry In depth
Immunohistochemistry as Biomarker Platform in Endometrial Cancer
Endometrial cancer is the most common malignancy of the female genital tract in Western countries, and its incidence is rapidly increasing in Asia. The standard treatment for women with endometrial cancer is s...
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Article
Sphingosine and FTY720 modulate pacemaking activity in interstitial cells of Cajal from mouse small intestine
Interstitial cells of Cajal (ICCs) are the pacemakers of the gastrointestinal tract, and transient receptor potential melastatin type 7 (TRPM7) and Ca2+ activated Cl− channels (ANO1) are candidate the generators ...
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Article
Poor prognosis of uterine serous carcinoma compared with grade 3 endometrioid carcinoma in early stage patients
Difference in prognosis between grade 3 endometrioid carcinoma (G3EC) of the endometrium and uterine serous carcinoma (USC) is controversial. In this study, we further evaluated the difference in prognosis, if...
