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Article
Open AccessLessons learned in measuring patient engagement in a Canada-wide childhood disability network
The CHILD-BRIGHT Network, a pan-Canadian childhood disability research Network, is dedicated to patient-oriented research, where numerous stakeholders, including patient-partners, researchers, and clinicians a...
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Article
Open AccessA Review of the Diagnostic and Therapeutic Gaps in Rosacea Management: Consensus Opinion
Rosacea is a common, chronic inflammatory disease characterized by both fluctuating and fixed heterogeneous signs such as facial erythema, papules/pustules, telangiectasia, acute vasodilation (flushing), and p...
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Article
Mental Health Providers’ Perspectives on What Helps and Hinders in Psychotherapy for Autistic Adults with Co-occurring Mental Health Problems
Autistic adults experience disproportionate rates of co-occurring mental health problems. Psychotherapy has been recognized as an appropriate treatment approach, but evidence is limited. Researchers used a qua...
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Article
Open AccessGATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms
Neoplasms originating from thymic T-cell progenitors and post-thymic mature T-cell subsets account for a minority of lymphoproliferative neoplasms. These T-cell derived neoplasms, while molecularly and genetic...
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Article
Open AccessEvaluation of Psychological Wellbeing and Social Impact of Combined Facial and Truncal Acne: a Multi-national, Mixed-Methods Study
Half of the individuals with facial acne develop truncal acne, but the impact of combined facial and truncal acne (CA) on patients’ quality of life is poorly researched.
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Article
Virtual Group–Based Mindfulness Intervention for Autistic Adults: a Feasibility Study
Although mindfulness-based interventions have been shown to be helpful in reducing psychological distress in autistic adults, limited research has explored virtual delivery in the autism community. We designed...
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Article
Open AccessImpact of Facial Atrophic Acne Scars on Quality of Life: A Multi-country Population-Based Survey
Acne affects more than 80% of adolescents and young adults, who most often develop acne scars. Supporting data on the effect of acne scars on patient’s health-related quality of life (HRQOL) are limited.
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Article
The Pathogenesis and Management of Acne-Induced Post-inflammatory Hyperpigmentation
Acne vulgaris is a common inflammatory disease. Among patients with darker skin phototypes (Fitzpatrick III–VI), the inflammatory processes of acne stimulate excess melanogenesis and abnormal melanin depositio...
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Article
Randomized Controlled Trial of a Video Gaming-Based Social Skills Program for Children on the Autism Spectrum
Families often face financial and geographical barriers to services for children with autism. The current study explored the effectiveness of a parent-supported adaptation of the computer game-based social ski...
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Article
Inpatient Child and Adolescent Psychiatry as an Extracurricular Venue for Medical Student and Resident Education and Professional Development: Story Time and Teen Talk
Comparatively little systematic data exists concerning medical student education from the inpatient child and adolescent psychiatry venue. Training in this venue is vulnerable to pressures including increasing...
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Article
Open AccessThe use of circulating cell-free tumor DNA in routine diagnostics of metastatic melanoma patients
Modern advances in technology such as next-generation sequencing and digital PCR make detection of minor circulating cell-free tumor DNA amounts in blood from cancer patients possible. Samples can be obtained ...
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Article
Open AccessSomatic alterations in circulating cell-free DNA of oesophageal carcinoma patients during primary staging are indicative for post-surgical tumour recurrence
Oesophageal cancer (OC) has high mortality. This study aims at determining the feasibility of liquid biopsies for genomic profiling in early stage OC, comparing two different technologies for mutational analys...
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Article
Open AccessClonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia
Deciphering the evolution of cancer cells under therapeutic pressure is a crucial step to understand the mechanisms that lead to treatment resistance. To this end, we analyzed whole-exome sequencing data of ei...
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Article
Open AccessWhy Topical Retinoids Are Mainstay of Therapy for Acne
Acne-focused dermatology expert groups have consistently recommended that most patients with acne be treated with a combination of topical retinoid and antimicrobial therapy. This is based on clinical data as ...
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Article
Open AccessAccess Barriers to Services by Immigrant Mothers of Children with Autism in Canada
Equal access for autism services remains suboptimal for diverse groups. In Canada, little is known about the barriers immigrant mothers face accessing services and support for their children with developmental...
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Article
Open AccessEfficacy of Secukinumab for Moderate-to-Severe Head and Neck Psoriasis Over 52 Weeks: Pooled Analysis of Four Phase 3 Studies
Psoriasis affecting the head and neck can be difficult to treat, and the presence of extensive and highly visible lesions may result in substantial psychosocial burdens. Secukinumab, a monoclonal antibody that...
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Article
Open AccessModerate and Severe Inflammatory Acne Vulgaris Effectively Treated with Single-Agent Therapy by a New Fixed-Dose Combination Adapalene 0.3 %/Benzoyl Peroxide 2.5 % Gel: A Randomized, Double-Blind, Parallel-Group, Controlled Study
A need exists for topical treatments in managing more severe inflammatory acne.
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Article
Open AccessMonitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations
We assessed the utility of droplet digital PCR (ddPCR) to evaluate the potential of using circulating tumour DNA (ctDNA) as a post therapy monitoring tool in melanoma by comparing it to serum LDH levels and RE...
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Chapter
Geology and Geomorphology of Coral Reefs in the Northwestern Hawaiian Islands
The Northwestern Hawaiian Islands (NWHI) comprise a portion of the middle of the 6,126 km long Hawaiian–Emperor seamount chain, considered to be the longest mountain chain in the world Grigg (1983) (Fig. 13.1)...
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Chapter
US Coral Reefs in the Line and Phoenix Islands, Central Pacific Ocean: History, Geology, Oceanography, and Biology
Pacific remote island areas (PRIA) are sovereign United States unincorporated and unorganized territories not falling within the jurisdiction of any other US territory or State (GAO 1997; US DOI 2003). There a...
