-
Chapter and Conference Paper
A Taxonomy for Platform Revenue Models: An Empirical-to-Conceptual Development Approach
In the field of Information Systems and Software Engineering, taxonomies are widely employed to organize and present well-designed knowledge. They play a crucial role in identifying relevant dimensions and cha...
-
Article
Open AccessBildung, Bildungserfolg und Schule
Der Beitrag zeichnet nach, dass sich gerade ambulante Hilfen zur Erziehung als unspezifische Hilfen verstehen lassen. Dabei wird eine breite Reihe von schul-, und bildungsrelevanten Fragen und Problematiken zu...
-
Article
Intensive chemotherapy followed by autologous stem cell transplantation in primary central nervous system lymphomas (PCNSLs). Therapeutic outcomes in real life—experience of the French Network
We analysed the therapeutic outcomes of all consecutive patients with primary central nervous system lymphoma (PCNSL) registered in the prospective French database for PCNSL and treated with intensive chemothe...
-
Article
Carfilzomib maintenance in newly diagnosed non-transplant eligible multiple myeloma
-
Chapter and Conference Paper
Encodability Criteria for Quantum Based Systems
Quantum based systems are a relatively new research area for that different modelling languages including process calculi are currently under development. Encodings are often used to compare process calculi. Q...
-
Article
Open AccessDifferential uptake of three clinically relevant allergens by human plasmacytoid dendritic cells
Human plasmacytoid dendritic cells (pDC) have a dual role as interferon-producing and antigen-presenting cells. Their relevance for allergic diseases is controversial. and the impact of pDC on allergic immune ...
-
Article
Open AccessFerroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes
Loss of TP53 and RB1 in treatment-naïve small cell lung cancer (SCLC) suggests selective pressure to inactivate cell death pathways prior to therapy. Yet, which of these pathways remain available in treatment-naï...
-
Article
Open AccessmTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
Cancer cells have a characteristic metabolism, mostly caused by alterations in signal transduction networks rather than mutations in metabolic enzymes. For metabolic drugs to be cancer-selective, signaling alt...
-
Article
Decreasing stand density favors resistance, resilience, and recovery of Quercus petraea trees to a severe drought, particularly on dry sites
Decreasing stand density increases resistance, resilience, and recovery of Quercus petraea trees to severe drought (2003), particularly on dry sites, and the...
-
Article
ATM activity in T cells is critical for immune surveillance of lymphoma in vivo
The proximal DNA damage response kinase ATM is frequently inactivated in human malignancies. Germline mutations in the ATM gene cause Ataxia-telangiectasia (A-T), characterized by cerebellar ataxia and cancer pre...
-
Chapter and Conference Paper
Dependencies of Agile Teams – An Analysis of the Scaled Agile Framework
Context: Agile teams are small teams with 3 to 9 members. In complex development endeavors such as systems engineering, an agile team has many dependencies, since it is not possible to incorporate all specialist ...
-
Article
Open AccessMYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer
MYC paralogs are frequently activated in small cell lung cancer (SCLC) but represent poor drug targets. Thus, a detailed map** of MYC-paralog-specific vulnerabilities may help to develop effective therapies for...
-
Chapter and Conference Paper
Comparing Scaling Agile Frameworks Based on Underlying Practices
Context: Agile software development is widely-used by small teams and has benefits like increased transparency or faster feedback. However, companies want to benefit from Agile also in the development of big prod...
-
Chapter and Conference Paper
Comparison of Agile Maturity Models
Context: Agile software development is widely used by small teams. Companies want to check their implementation of Agile for different reasons. Many Agile Maturity Models (AMM) exist that support practitioners in...
-
Article
Open AccessOvercoming EGFRG724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors
The emergence of acquired resistance against targeted drugs remains a major clinical challenge in lung adenocarcinoma patients. In a subgroup of these patients we identified an association between selection of EG...
-
Article
AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer
A fundamental principle in malignant tranformation is the ability of cancer cells to escape the naturally occurring cell-intrinsic responses to DNA damage. Tumors progress despite the accumulation of DNA lesio...
-
Article
Open AccessClonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia
Deciphering the evolution of cancer cells under therapeutic pressure is a crucial step to understand the mechanisms that lead to treatment resistance. To this end, we analyzed whole-exome sequencing data of ei...
-
Article
Open AccessTargeting a non-oncogene addiction to the ATR/CHK1 axis for the treatment of small cell lung cancer
Small cell lung cancer (SCLC) is a difficult to treat subtype of lung cancer. One of the hallmarks of SCLC is its almost uniform chemotherapy sensitivity. However, chemotherapy response is typically transient ...
-
Chapter and Conference Paper
Why Do We Do Software Process Improvement?
Every company tries to improve its overall business, especially in the fast and reacting world of software. For these improvement activities, the development process is a major aspect. Our goal was the elicita...
-
Chapter
Public Sector Accounting and Auditing in Switzerland
In the following chapter, the state and government architecture in Switzerland and its political system is discussed, as this is the basis for the understanding of public financial management in Switzerland. B...
