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Open AccessAuthor Correction: Recording of pig neuronal activity in the comparative context of the awake human brain
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Article
Myofiber-type-dependent ‘boulder’ or ‘multitudinous pebble’ formations across distinct amylopectinoses
At least five enzymes including three E3 ubiquitin ligases are dedicated to glycogen’s spherical structure. Absence of any reverts glycogen to a structure resembling amylopectin of the plant kingdom. This amyl...
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Article
Open AccessOVOL2 sustains postnatal thymic epithelial cell identity
Distinct pathways and molecules may support embryonic versus postnatal thymic epithelial cell (TEC) development and maintenance. Here, we identify a mechanism by which TEC numbers and function are maintained p...
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Article
Open AccessMaintenance of pig brain function under extracorporeal pulsatile circulatory control (EPCC)
Selective vascular access to the brain is desirable in metabolic tracer, pharmacological and other studies aimed to characterize neural properties in isolation from somatic influences from chest, abdomen or li...
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Article
LY6E is a pan-coronavirus restriction factor in the respiratory tract
LY6E is an antiviral restriction factor that inhibits coronavirus spike-mediated fusion, but the cell types in vivo that require LY6E for protection from respiratory coronavirus infection are unknown. Here we ...
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Article
Open AccessAuthor Correction: Recording of pig neuronal activity in the comparative context of the awake human brain
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Article
Open AccessRecording of pig neuronal activity in the comparative context of the awake human brain
Gyriform mammals display neurophysiological and neural network activity that other species exhibit only in rudimentary or dissimilar form. However, neural recordings from large mammals such as the pig can be a...
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Article
Open AccessThe nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization
Lamins and transmembrane proteins within the nuclear envelope regulate nuclear structure and chromatin organization. Nuclear envelope transmembrane protein 39 (Net39) is a muscle nuclear envelope protein whose...
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Open AccessIn vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse
Duchenne muscular dystrophy (DMD) is a fatal genetic disorder caused by mutations in the dystrophin gene. To enable the non-invasive analysis of DMD gene correction strategies in vivo, we introduced a lucifera...
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A Twist2-dependent progenitor cell contributes to adult skeletal muscle
Skeletal muscle possesses remarkable regenerative potential due to satellite cells, an injury-responsive stem cell population located beneath the muscle basal lamina that expresses Pax7. By lineage tracing of ...
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Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development
Transcription of a long non-coding RNA, known as upperhand (Uph) located upstream of the HAND2 transcription factor is required to maintain transcription of the Hand2 gene by RNA polymerase, and blockade of Uph e...
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Correction: Corrigendum: Hypoxia fate map** identifies cycling cardiomyocytes in the adult heart
Nature 523, 226–230 (2015); doi:10.1038/nature14582 In this Letter we omitted to include the accession number for our RNA-seq data. The data are deposited in the Sequence Read Archive database under the access...
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Hypoxia fate map** identifies cycling cardiomyocytes in the adult heart
Fate-map** hypoxic cells in the mouse heart identifies a rare population of cycling cardiomyocytes, which show characteristics of neonatal cardiomyocytes, including smaller size and mononucleation, and contr...
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Open AccessTrans-cranial opening of the blood-brain barrier in targeted regions using astereotaxic brain atlas and focused ultrasound energy
The blood-brain barrier (BBB) protects the brain by preventing the entry of largemolecules; this poses a major obstacle for the delivery of drugs to the brain. Anovel technique using focused ultrasound (FUS) e...
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Myomaker is a membrane activator of myoblast fusion and muscle formation
Fusion of myoblasts is essential for the formation of multi-nucleated muscle fibres. However, the identity of muscle-specific proteins that directly govern this fusion process in mammals has remained elusive. ...
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Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress
Signaling by the calcium-dependent phosphatase calcineurin profoundly influences the growth and gene expression of cardiac and skeletal muscle. Calcineurin binds to calsarcins, a family of muscle-specific prot...
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Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1−/− mice
Hypoxia-inducible factor (HIF) transcription factors respond to multiple environmental stressors, including hypoxia and hypoglycemia. We report that mice lacking the HIF family member HIF-2α (encoded by Epas1) ha...
